Search
Skip to Search Results- 1Acevedo Morantes, Claudia Y
- 1Aguzzi, Adriano
- 1Bao, Hua
- 1Baral, Pravas K.
- 1Braithwaite, Shannon Lynn
- 1Cardenas, Maria Eugenia
- 28Graduate and Postdoctoral Studies (GPS), Faculty of
- 28Graduate and Postdoctoral Studies (GPS), Faculty of/Theses and Dissertations
- 1Agricultural, Food and Nutritional Science, Department of
- 1Agricultural, Food and Nutritional Science, Department of/Journal Articles (Agricultural, Food and Nutritional Science)
- 1Computing Science, Department of
- 1Computing Science, Department of/Technical Reports (Computing Science)
-
Quantitative Label-Free Comparative Proteomic Analyses of Eukaryotic Tissues via Mass Spectrometry
DownloadFall 2018
In recent years, rapid advances in genomic and transcriptomic sequencing technologies have enabled the compilation of vast libraries of protein sequences and thus an explosion in bioinformatics-based fields of research. Among these is proteomics – the study of global protein abundance within a...
-
Fall 2016
Apolipoprotein E (APOE) ɛ4 and Clusterin (CLU) C alleles are risk factors for Alzheimer’s disease (AD) and preclinical cognitive and memory decline in older adults. We investigated whether memory resilience to genetic risk (i.e., Apolipoprotein E [APOE] ɛ4, Clusterin [CLU] CC, and a high additive...
-
Structure and dynamics of biomolecules: probing muscle regulation, prion protein unfolding, and drug insertion into DNA by nuclear magnetic resonance spectroscopy
DownloadSpring 2011
Nuclear magnetic resonance (NMR) spectroscopy is a powerful approach to study the structure and dynamics of macromolecules in a close-to-native solution environment. In the present thesis I present my investigation of protein and nucleic acid structure and dynamics in a wide variety of biological...
-
Synthesis of porphyrin-based multimeric fluorescent compounds and studies towards the formation of cis-anti-cis linear triquinane
DownloadFall 2011
Prion diseases are life-threatening diseases found in many mammals, including humans, and there is still no effective vaccine, treatment or therapy. In Chapter 1, a concise and effective synthetic route was reported to synthesize a library of porphyrin-based multimeric fluorescent compounds with...
-
2014
Maani, Rouzbeh, Kalra, Sanjay, Yang, Yee-Hong
In this paper, we applied texture analysis to evaluate cerebral degeneration in amyotrophic lateral sclerosis (ALS). Two well-known methods, the gray level co-occurrence matrix (GLCM) and the gray level aura matrix (GLAM) were employed to extract texture features from routine T1 and T2 MR images....
-
The Prion Protein: Modulation of Potassium Channels and a Novel Mouse Model of a Disease-Causing Hydrophobic Domain Insertion Mutation
DownloadSpring 2016
Mercer, Robert Corrigan Curtis
Prion diseases are invariably fatal neurodegenerative diseases of humans and other mammals. While they can manifest as sporadic, infectious or genetic etiologies, the central event in prion disease is the structural conversion of the prion protein (PrPC) to an alternative conformer PrPSc. PrP is...
-
Fall 2014
Scientists and clinicians involved in the development of biomarkers confront with the challenge of selecting the best analytical methods among dozens that have been reported in the literature. Creation of new and improvement of exist technologies is an integral part of the pathway to analytical...
-
TIMP1 and MMP9 are predictors of mortality in septic patients in the emergency department and intensive care unit unlike MMP9/TIMP1 ratio: Multivariate model
Download2017-01-01
Niño, Maria Eugenia, Serrano, Sergio Eduardo, Niño, Daniela Camila, McCosham, Diana Margarita, Cardenas, Maria Eugenia, Villareal, Vivian Poleth, Schulz, Richard
Matrix metalloproteinases and tissue inhibitors of metalloproteinases could be promising biomarkers for establishing prognosis during the development of sepsis. It is necessary to clarify the relationship between matrix metalloproteinases and their tissue inhibitors. We conducted a cohort study...
-
Spring 2018
Lung cancer has the highest mortality rates of all cancers worldwide, with a 5-year survival rate less than 15%. Screening methods are in need for the high risk population, as lung cancer is asymptomatic in its early stages. Proper screening methods would allow earlier diagnosis and curative...