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Skip to Search Results- 2Veldhoen, Richard
- 1Abdualmjid,Reem J
- 1Abdurrahim, Amna E.
- 1Araya, Luam Ellen
- 1Baghdasarian, Argishti
- 1Banadyga, Logan Elliott
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Investigation of BCL-2 interacting killer (BIK) as a breast cancer biomarker and its role in failed apoptosis
DownloadSpring 2019
Breast cancer is the number one cause of cancer-associated deaths in women worldwide. It can be broadly classified into estrogen receptor (ER) positive or -negative subtypes which form the basis of treatment. Despite the therapeutic advancements, more than half a million women annually succumb to...
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Spring 2012
Apoptosis, an evolutionarily conserved cell death programme, is a potent barrier against virus infection. Central to this process are mitochondria, which harbour cytochrome c and other apoptosis-inducing factors. Once released, these factors activate a caspase cascade that culminates in cell...
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Mitochondrial Dysfunction and Induction of Apoptosis in Hepatocellular Carcinoma and Cholangiocarcinoma Cell Lines by Thymoquinone
DownloadSpring 2015
Thymoquinone, the plant-based bioactive constituent derived from the volatile oil of Nigella sativa, has been shown to possess considerable anti-neoplastic activity. The present study aimed to investigate the anti-tumour property of TQ against hepatocellular carcinoma (HepG2) and...
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Spring 2012
Modulator of apoptosis 1 (MOAP-1) is a BH3-like protein that plays a key role in death receptor-dependent apoptosis and cooperates with the tumor suppressor protein Ras association domain family 1A (RASSF1A) to promote Bax activation during cell death. Although loss of RASSF1A expression is...
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Fall 2011
Taxanes are used for the treatment of breast, ovarian, and lung cancer. Unfortunately, taxane based therapy—the current treatment for metastatic breast cancer—has substantial shortcomings including myelosupression, neurotoxicity, and frequently acquired resistance. Our present understanding of...
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Fall 2011
Taxanes are used for the treatment of breast, ovarian, and lung cancer. Unfortunately, taxane based therapy—the current treatment for metastatic breast cancer—has substantial shortcomings including myelosupression, neurotoxicity, and frequently acquired resistance. Our present understanding of...
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Poxviral manipulation of Bcl-2 proteins: fowlpox virus FPV039 and deerpox virus DPV022 inhibit apoptosis by neutralising Bak and Bax, while Noxa contributes to vaccinia virus-induced apoptosis
DownloadSpring 2011
Poxviruses are renowned for encoding proteins that modulate virtually every aspect of the host immune system. One effective barrier against virus infection is apoptosis, a form of programmed cell death. Apoptosis is controlled at the mitochondria by pro- and anti-apoptotic members of the highly...
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Regulation of Pancreatic β-cell Life and Death in the Context of Type 2 Diabetes: Study of the Potential Implication of the Orphan Nuclear Receptor NR4A3/Nor1 and the NZF Transcription Factor ST18.
DownloadFall 2017
Background: The insulin-secreting pancreatic beta-cell plays a central role in the maintenance of glucose homeostasis and in the pathogenesis of both type 1 and type 2 diabetes mellitus. In both cases, production of pro-inflammatory cytokines causes beta-cell apoptosis, which results in the...