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Evaluating the Role of Bacterial Lipopolysaccharide on Etiology and Pathogenesis of Transmissible Spongiform Encephalopathies
DownloadFall 2014
Transmissible spongiform encephalopathies (TSEs) or otherwise known as prion diseases are a class of fatal neurodegenerative diseases related to irreversible brain damage. Presently, there is no effective treatment or preventive strategy for this disease because the etiology and biological...
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Spring 2010
As the demand for oil and gas resources increases pipeline construction pushes further into the Arctic and sub-Arctic regions. Consequently, these buried pipelines suffer much harsh environmental and complex loading conditions. Moreover, to increase the transporting efficiency, larger size pipes...
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Fall 2009
The majority of triacylglycerol (TG) utilized for very-low density lipoproteins (VLDL) assembly is derived from lipolysis-reesterification of TG stored in lipid droplets (LDs). At least two types of LDs exist in hepatocytes – cytosolic LDs (CLDs) and the microsomal-associated luminal LDs (LLDs)....
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Fall 2016
Apolipoprotein E (APOE) ɛ4 and Clusterin (CLU) C alleles are risk factors for Alzheimer’s disease (AD) and preclinical cognitive and memory decline in older adults. We investigated whether memory resilience to genetic risk (i.e., Apolipoprotein E [APOE] ɛ4, Clusterin [CLU] CC, and a high additive...
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Fall 2014
The pairing of implantable micro-electrode arrays with micro-electronic devices allows the observation of neural activity within nervous systems in a more comprehensive and potentially more effective way compared to single electrode recording. State-of-the-art tethered recording systems use...
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The roles of Pbx and Meis TALE-class homeodomain transcription factors in vertebrate neural patterning
DownloadFall 2010
One of the major goals of developmental biology is to understand how specialized groups of cells arise from an initially unspecified cell population. The vertebrate hindbrain is transiently segmented along its anterior-posterior axis into lineage-restricted compartments called rhombomeres, making...