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Skip to Search Results- 1Alvarado, Laura
- 1Anderson, Sharon
- 1Anderson, Sharon D
- 1Arvanitidis, Anastasia P
- 1Auriat, Angela Michelle
- 1Caliaperumal, Jayalakshmi
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Spring 2012
Stroke, a reduction in blood flow to the brain, activates various proteins that contribute to neuronal death. The matrix metalloproteinases (MMPs), specifically MMP2 and MMP9, are important in maintaining the blood brain barrier (BBB). After a stroke the BBB permeability increases which is...
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Spring 2024
Intracerebral hemorrhage (ICH), a devastating stroke caused by the rupture of vasculature in the brain, is responsible for <20% of all strokes, yet accounts for a disproportionately high burden of stroke related death and disability. The formation and degradation of the hematoma (blood clot)...
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External sensors for the feedback control of functional electrical stimulation assisted walking
DownloadFall 2010
Functional electrical stimulation (FES) is a rehabilitative technology that can be used to improve walking in individuals with mobility impairments due to neurologic injury or disease. Feedback is essential for efficient FES-assisted walking. The overall goal of my project was to investigate...
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Hypothermia and the Evaluation of Combination Therapies for Neonatal Hypoxic-Ischemic Brain Damage
DownloadFall 2016
Hypoxic-ischemic brain damage (HIBD) is still of major concern in the neonatal period, resulting in chronic neurological sequelae stemming from damage to the term newborn brain. Full-body and focal-head cooling within 6 hours of birth have proven neuroprotective in human newborns and various...
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Influence of therapeutic hypothermia on neuroprotection and post-ischemic plasticity in a rat model of global ischemia
DownloadFall 2011
Blood flow to the brain may be disrupted by either a stroke (such as focal ischemia or hemorrhage) or cardiac arrest, where the whole brain becomes ischemic. Both forms of injury result in irreversible neuronal loss leading to neurological impairments and a decrease in the quality of life....
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Intracortical administration of pleiotrophin in ischemic stroke: investigating functional outcomes and glial expression
DownloadSpring 2023
Ischemic stroke is the leading cause of disability and third leading cause of death in Canada, exerting a serious burden on stroke survivors, their families, and healthcare resources. Characterized by brain damage due to loss of blood flow and oxygen supply, ischemic stroke is characterized by...
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Fall 2020
Intracerebral hemorrhage (ICH), when a blood vessel ruptures within the brain, affects approximately 15% of stroke victims in Canada. There are no proven neuroprotective treatments ICH but two therapies, therapeutic hypothermia (TH) and iron-chelators, have gained preclinical and clinical...
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Spring 2019
Walking is a locomotor task that integrates information from all over the nervous system. The lumbosacral spinal cord houses neural networks that contribute to locomotion. These networks dominate locomotor activity during development and may provide suitable targets for restoring function after...
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Spring 2014
Bleeding within the brain parenchyma causes a severe form of stroke named intracerebral hemorrhagic stroke (ICH). An understanding of how brain injury occurs after an ICH may suggest alternative therapies. For this reason, the current dissertation focuses on two important questions of how the...
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Fall 2016
This thesis discusses the pathophysiological mechanisms underlying neuromotor impairments in people with spastic cerebral palsy (CP). Ninety percent of people with CP have spastic CP and 60% have bilateral motor impairments. The first two chapters introduce CP and review the mechanisms known to...