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- 11Cognitive impairment
- 4Dementia
- 4Swallowing
- 3Amyloid precursor protein
- 3Interventions
- 23Graduate and Postdoctoral Studies (GPS), Faculty of
- 23Graduate and Postdoctoral Studies (GPS), Faculty of/Theses and Dissertations
- 10Nursing, Faculty of
- 8Nursing, Faculty of/Chronicity
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- 4Rehabilitation Medicine, Faculty of/Speech Pathology and Audiology
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Role of Glutamate and GABA in a mouse model expressing mutant human APP in the absence of NPC1 protein
DownloadSpring 2013
Cholesterol plays a critical role in Alzheimer’s disease (AD) pathogenesis, but the underlying mechanisms remain unclear. To address this issue we have generated a line of ANPC transgenic mice that overexpress mutant-human amyloid precursor protein in the absence of cholesterol transporting...
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Roles of the Insulin-like Growth Factor-II/Cation-independent Mannose 6-phosphate Receptor and Cathepsin D in Alzheimer’s Disease Pathology
DownloadSpring 2016
Alzheimer’s disease (AD) is the most common type of senile dementia affecting the elderly. A critical contributing factor to the neurodegeneration and development of AD pathology stems from the processing of amyloid precursor protein (APP), leading to the generation of β-amyloid (Aβ) peptides....
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Fall 2020
Tauopathies are a class of neurological disorders associated with the aggregation of the tau protein into neurofibrillary tangles. The most prominent tauopathy is Alzheimer’s disease (AD), which presents as two forms: early onset (familial, fAD) and late onset (sporadic, sAD). sAD does not have a...
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2011-06-28
Ostertag, Amanda, Ketch, Rhonda, Moncks, Nadine, Erickson, Dorie
Amyotrophic Lateral Sclerosis (ALS) is a motor neuron disease characterized by the degeneration of both upper and lower motor neurons. These impairments cause functional limitations in many motor systems, including those supporting respiration and swallowing. As ALS progresses, specific...
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The use of a volitional airway protection technique by a patient with amyotrophic lateral sclerosis and cognitive impairment
The use of a volitional airway protection technique by a patient with amyotrophic lateral sclerosis and cognitive impairment
Download2011-01-13
Cleary, Stuart, Costar, Allison, Prior, Jacqueline
The purpose of this pilot study is to determine if an individual with ALS and frontotemporal lobar dementia can learn a volitional airway protection technique and, if so, does this treatment have a beneficial effect on respiration and swallowing?
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Thermal response of amyloidogenic elements in cultured N2a cells: potential relevance to Alzheimer’s disease pathology
DownloadFall 2020
Alzheimer’s disease (AD) weighs a large burden on health care systems, families and caregiving networks around the world. It is the most common dementia afflicting elderly individuals, and causes many debilitating symptoms, including memory loss, mood swings and confusion which progress in...
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Use of autobiographical memory cues as cognitive support for episodic memory: Comparison of individuals with mild-stage Alzheimer's disease and healthy older adults
DownloadFall 2009
The purpose of the study was to examine the effectiveness of autobiographical memories to support the improvement of episodic memory (i.e., word recall) in patients with mild- stage Alzheimer’s Disease (AD) and healthy older adults. Participants included 20 healthy young-old adults (M Age =...
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Zebrafish Targeted Mutagenesis to Unveil Normal Physiological Functions of, and Interactions between, Prion Protein (PrP) and Amyloid Precursor Protein (APP): Relevance to Alzheimer’s disease
DownloadSpring 2017
Much of the work on Prion Protein (PrPC) and Amyloid Precursor Protein (APP) biology has focused on the contributions of their misfolded forms or aggregated metabolites to prion diseases and Alzheimer’s disease, respectively. As subversion/partial loss of some normal functions are also likely...