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Correlation of Subregional Hippocampal Thickness Abnormalities with Positron Emission Tomography Phosphorylated Tau Measurements in Patients with Mild Cognitive Impairment and Alzheimer's Disease
DownloadFall 2023
Alzheimer’s disease (AD) is the most common cause of dementia and is an emerging public health crisis with 150 million cases projected globally by 2050. Biomarkers are playing an emerging role in AD research - however, existing biomarkers have substantial limitations. Magnetic Resonance Imaging...
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Fall 2022
While great advancements have been made in the field of tau biology, one particularly elusive component is the significance of structural variance of tau aggregates linked to disease: we see great structural heterogeneity among the aggregates obtained from various tauopathies despite being made...
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The Humanization of Rodent Beta-Amyloid: The Aggregative and Toxic Properties of Amino-Terminal Beta-Amyloid Mutations
DownloadSpring 2020
Human β-amyloid1-42 (hAβ1-42) peptides are known to self-aggregate into oligomers that contribute to the degeneration of neurons and development of Alzheimer's disease (AD) pathology. Unlike humans, rodents do not develop AD, possibly due to differences in three amino acids (R5G, Y10F and H13R)...
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Fall 2014
Scientists and clinicians involved in the development of biomarkers confront with the challenge of selecting the best analytical methods among dozens that have been reported in the literature. Creation of new and improvement of exist technologies is an integral part of the pathway to analytical...