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- 2Alzheimer's Disease
- 1Amyloid Beta
- 1Desorption Ionization on Silicon
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- 1Glancing Angle Deposition
The Humanization of Rodent Beta-Amyloid: The Aggregative and Toxic Properties of Amino-Terminal Beta-Amyloid MutationsDownload
Human β-amyloid1-42 (hAβ1-42) peptides are known to self-aggregate into oligomers that contribute to the degeneration of neurons and development of Alzheimer's disease (AD) pathology. Unlike humans, rodents do not develop AD, possibly due to differences in three amino acids (R5G, Y10F and H13R)...
Scientists and clinicians involved in the development of biomarkers confront with the challenge of selecting the best analytical methods among dozens that have been reported in the literature. Creation of new and improvement of exist technologies is an integral part of the pathway to analytical...