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Fall 2017

Stubbins, Ryan J

Myristoylation is the post-translational modification of proteins with a 14-carbon fatty- acid by N-myristoyltransferase 1 (NMT1) or NMT2. Myristoylation is key to protein membrane binding and cell survival. Bioinformatics data suggests NMT mRNA expression impacts overall survival (OS) in AML. We...

2012

Sun, Nian, Klassen, John S., Bai, Yu, Liu, Lan, Xia, Li, Lowary, Todd L.

The interactions between 3-O-methyl-mannose polysaccharides (MMPs), extracted from Mycobacterium smegmatis (consisting of a mixture of MMP-10, -11, -12 and -13) or obtained by chemical synthesis (MMP-5s, -8s, -11s and -14s), and linear saturated and unsaturated fatty acids (FAs), and a commercial...

2012

Xia, Li, Sun, Nian, Klassen, John S., Liu, Lan, Bai, Yu, Lowary, Todd L.

The interactions between 3-O-methyl-mannose polysaccharides (MMPs), extracted from Mycobacterium smegmatis (consisting of a mixture of MMP-10, -11, -12 and -13) or obtained by chemical synthesis (MMP-5s, -8s, -11s and -14s), and linear saturated and unsaturated fatty acids (FAs), and a commercial...

2011

Riediger, Natalie D., Bruce, Sharon G., Young, T. Kue

"Introduction: Despite high diabetes rates among Canadian First Nations people, little is known about their cardiovascular disease risk. Our aim was to describe the apolipoprotein profile with respect to cardiovascular risk in a Canadian First Nation community. Methods: In 2003, a representative...

Spring 2020

Sharma, Abhinav

Introduction: Diabetes and heart failure (HF) place a large burden on healthcare systems and are associated with increased risk for death, including sudden cardiac death (SCD). However, causes of death have not been fully explored and evidence for primary prevention...

2005-11-22

Liu, Juan, Hanley, Anthony J. G., Young, T. Kue, Harris, S. B., Zinman, Bernard

"Objective: To compare the characteristics and prevalence of the metabolic syndrome (MetS) among Native Indians, Inuit, andnon-Aboriginal Canadians. Methods: The study was based on four cross-sectional studies conducted in the late 1980s and early 1990s involving threeethnic groups living in...

Fall 2012

Anderson, Sarah J

The current shortage of islet tissue from cadaveric human donors is not sustainable and will preclude islet transplantation from becoming a widespread therapeutic treatment for those with type 1 diabetes. A potential alternative source of tissue may be through isolating, expanding, and...

2011

Borthwick, Faye, Field, Catherine J., Wang, Ye, Proctor, Spencer D., Jaeschke, Anja, Shi, Danni, Hassanali, Zahra, Ruth, Megan, Russell, James C., Mangat, Rabban, Vine, Donna F., Lu, Jing

There is increasing interest in the potential chronic beneficial effects of dietary n-3 PUFA on the metabolic syndrome (MetS) and associated cardiovascular complications. We have recently established that increased dietary n-3 PUFA has a profound acute benefit on fasting lipids and the...

2013-03-14

Sherman, Philip - Scientific Director, CIHR Institute of Nutrition, Metabolism and Diabetes (INMD)

Dr. Philip Sherman (Scientific Director, CIHR Institute of Nutrition, Metabolism and Diabetes [INMD]) outlined the 2009-2014 Strategic Priorities of INMD. These include Food and Health; Environments, Genes, & Chronic Disease; Obesity and Healthy Body Weight: Seeking Solutions; and Continuum of...

Spring 2024

Verhoeff, Kevin KW

Twenty-years ago Shapiro et al. revolutionized islet transplantation (ITx), realizing the potential for a cell-based diabetes treatment. Despite improvements, ITx remains restricted by organ donor limitations and immunosuppression. Stem cell (SC)-derived ITx (SC Tx) could eliminate these...