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Author / Creator / Contributor
- 1Bennet, Andrew J.
- 1Chan, Jefferson
- 1Davies, Gideon J.
- 1He, Yuan
- 1Macauley, Matthew S.
- 1Stubbs, Keith A.
Subject / Keyword
- 1Capillary Electrophoresis
- 1Carbohydrate Biosynthesis
- 1Carbohydrate Chemistry
- 1Carbohydrate Glycoprotein
- 1Glycobiology
- 1Glycosidases
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Metabolism of vertebrate amino sugars with N-glycolyl groups: Intracellular β-O-linked N-glycolylglucosamine (GlcNGc), UDP-GlcNGc,and the biochemical and structural rationale for the substrate tolerance of β-O-linked& beta;-N-acetylglucosaminidase
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Vocadlo, David J. , Chan, Jefferson, Whitworth, Garrett A., Macauley, Matthew S., Stubbs, Keith A., Varki, Ajit, Davies, Gideon J., Yuzwa, Scott, Zandberg, Wesley, Bennet, Andrew J., He, Yuan
The O-GlcNAc modification involves the attachment of single β-O-linked N-acetylglucosamine residues to serine and threonine residues of nucleocytoplasmic proteins. Interestingly, previous biochemical and structural studies have shown that O-GlcNAcase (OGA), the enzyme that removes O-GlcNAc from...
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