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Skip to Search Results- 20Plastow, Graham S.
- 9Harding, John C. S.
- 9Stothard, Paul
- 8Bao, Hua
- 8Dekkers, Jack C. M.
- 8Lunney, Joan K.
- 12PigGen Canada
- 12PigGen Canada/Journal Articles
- 7Roy Berg Kinsella Research Ranch
- 7Roy Berg Kinsella Research Ranch/Journal Articles (Kinsella Ranch)
- 2Agricultural, Food and Nutritional Science, Department of
- 2Agricultural, Food and Nutritional Science, Department of/Journal Articles (Agricultural, Food and Nutritional Science)
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Genome-wide analysis of thetranscriptional response to porcinereproductive and respiratory syndromevirus infection at the maternal/fetalinterface and in the fetus
Download2016-01-01
Wilkinson, Jamie M., Bao, Hua, Ladinig, Andrea, Hong, Linjun, Stothard, Paul, Lunney, Joan K., Plastow, Graham S., Harding, John C. S.
Background:Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) infection of pregnant pigs can result incongenital infection and ultimately fetal death. Little is known about immune responses to infection at thematernal-fetal interface and in the fetus itself, or the molecular events...
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Genome-wide whole blood microRNAome and transcriptome analyses revealed miRNA-mRNA regulated host response to foodborne pathogen Salmonella infection in swine
Download2015-07-31
Arantes, Adriano S., Tuggle, Christopher K., Guan, Le L., Bearson, Shawn M.D., Sun, Xu, Plastow, Graham S., Kommadath, Arun, Bao, Hua, Stothard, Paul, Liang, Guanxiang
To understand the role of miRNAs in regulating genes involved in host response to bacterial infection and shedding of foodborne pathogens, a systematic profiling of miRNAs and mRNAs from the whole blood of pigs upon Salmonella challenge was performed. A total of 62 miRNAs were differentially...
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Genomic Analysis of IgG Antibody Response to Common Pathogens in Commercial Sows in Health-Challenged Herds
Download2020-10-23
Sanglard, Leticia P., PigGen Canada, Mote, Benny E., Willson, Philip, Harding, John C. S., Plastow, Graham S., Dekkers, Jack C. M., Serao, Nick V. L.
Losses due to infectious diseases are one of the main factors affecting productivity in the swine industry, motivating the investigation of disease resilience-related traits for genetic selection. However, these traits are not expected to be expressed in the nucleus herds, where selection is...
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Novel Resilience Phenotypes Using Feed Intake Data From a Natural Disease Challenge Model in Wean-to-Finish Pigs
Download2019-01-01
Putz, Austin M., Harding, John C. S., Dyck, Michael K., Fortin, F., Plastow, Graham S., Dekkers, Jack C. M., PigGen Canada
The objective of this study was to extract novel phenotypes related to disease resilience using daily feed intake data from growing pigs under a multifactorial natural disease challenge that was designed to mimic a commercial environment with high disease pressure to maximize expression of...
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2018-01-01
Walker, Lianna R., Engle, Taylor B., Vu, Hiep, Tosky, Emily R., Nonneman, Dan J., Smith, Timothy P. L., Borza, Tudor, Burkey, Thomas E., Plastow, Graham S., Kachman, Stephen D., Ciobanu, Daniel C.
Porcine circovirus 2 (PCV2) is a circular single-stranded DNA virus responsible for a group of diseases collectively known as PCV2 Associated Diseases (PCVAD). Variation in the incidence and severity of PCVAD exists between pigs suggesting a host genetic component involved in pathogenesis. A...
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2019-01-01
Lim, Kyu-Sang, Dong, Qian, Moll, Pamela, Vitkovska, Jana, Wiktorin, Gregor, Bannister, Stephanie, Daujotyte, Dalia, Tuggle, Christopher K., Lunney, Joan K., Plastow, Graham S., Dekkers, Jack C. M.
Background:Gene expression profiling in blood is a potential source of biomarkers to evaluate or predict phenotypic differences between pigs but is expensive and inefficient because of the high abundance of globin mRNA in porcine blood. These limitations can be overcome by the use of QuantSeq...
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The genetic basis of natural antibody titersof young healthy pigs and relationshipswith disease resilience
Download2020-01-01
Chen, Yulu, Tibbs Cortes, Laura E., Ashley, Carolyn, Putz, Austin M., Lim, Kyu-Sang, Dyck, Michael K., Fortin, Frederic, Plastow, Graham S., Dekkers, Jack C. M., Harding, John C. S., PigGen Canada
Background Disease resilience is the ability to maintain performance under pathogen exposure but is difficult to select for because breeding populations are raised under high health. Selection for resilience requires a trait that is heritable, easy to measure on healthy animals, and genetically...
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Transcriptomic and epigenetic profiling of the lung of influenza-infected pigs: A comparison of different birth weight and Susceptibility groups
Download2015-09-22
Harding, John C.S., Foxcroft, George R., Gunvaldsen, Rayna E., Dyck, Michael K., Plastow, Graham S., Detmer, Susan E., Wilkinson, Jamie M., Dixon, Walter T.
Influenza viruses are a common cause of respiratory disease in swine. Infections range in severity from asymptomatic to causing significant morbidity. The main objective of this study was to compare lung transcriptomic and epigenetic responses to influenza infection in pigs from high or low birth...
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2016-03-07
Raszek, Mikolaj M., Plastow, Graham S., Guan, Le L.
Although infectious diseases impose a heavy economic burden on the cattle industry, the etiology of many disorders that affect livestock is not fully elucidated, and effective countermeasures are often lacking. The main tools available until now have been vaccines, antibiotics and antiparasitic...