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Skip to Search Results- 7Mangat, Rabban
- 6Field, Catherine J.
- 6Proctor, Spencer D.
- 4Azad, Meghan B.
- 4Kozyrskyj, Anita L.
- 4Vine, Donna F.
- 10Agricultural, Food and Nutritional Science, Department of
- 10Agricultural, Food and Nutritional Science, Department of/Journal Articles (Agricultural, Food and Nutritional Science)
- 1Nursing, Faculty of
- 1Nursing, Faculty of/Health Equity
- 1Graduate and Postdoctoral Studies (GPS), Faculty of
- 1Graduate and Postdoctoral Studies (GPS), Faculty of/Theses and Dissertations
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Arterial retention of remnant lipoproteins ex-vivo is increased during insulin resistance due to increased arterial biglycan and production of cholesterol-rich atherogenic particles, that can be improved by ezetimibe in the JCR:LA-cp rat
Download2012
Russell, James C., Proctor, Spencer D., Uwiera, Richard R. E., Vine, Donna F., Mangat, Rabban, Hassanali, Zahra, Cheeseman, Christopher I., Borthwick, Faye, Warnakula, Samantha
Background Literature supports the “response-to-retention” hypothesis—that during insulin resistance, impaired metabolism of remnant lipoproteins can contribute to accelerated cardiovascular disease progression. We used the JCR:LA-cp rat model of metabolic syndrome (MetS) to determine the extent...
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Cardiomyocyte antihypertrophic effect of adipocyte tissue conditioned medium from rats and its abrogation by obesity is mediated by the leptin to adiponectin ratio
Download2016
Karmazyn, Morris, Proctor, Spencer D., Mangat, Rabban, Gan, Xiaohong T., Bairwa, Suresh C., Rajapurohitam, Venkatesh
White adipocytes are known to function as endocrine organs by secreting a plethora of bioactive adipokines which can regulate cardiac function including the development of hypertrophy. We determined whether adipose tissue conditioned medium (ATCM) generated from the epididymal regions of normal...
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Chronic dietary n-3 PUFA intervention improves dyslipidaemia and subsequent cardiovascular complications in the JCR:LA-cp rat model of the metabolic syndrome
Download2011
Borthwick, Faye, Field, Catherine J., Wang, Ye, Proctor, Spencer D., Jaeschke, Anja, Shi, Danni, Hassanali, Zahra, Ruth, Megan, Russell, James C., Mangat, Rabban, Vine, Donna F., Lu, Jing
There is increasing interest in the potential chronic beneficial effects of dietary n-3 PUFA on the metabolic syndrome (MetS) and associated cardiovascular complications. We have recently established that increased dietary n-3 PUFA has a profound acute benefit on fasting lipids and the...
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Differential expression of hypothalamic metabolic and inflammatory genes in response to short-term calorie restriction in juvenile obese- and lean-prone JCR rats
Download2015
Vine, Donna F., Jacobs, Rene, Pierce, W.D., Heth, C.D., Russell, Jim, Proctor, Spencer D., Borthwick, Faye, Nelson, Randy, Diane, Abdoulaye, Mangat, Rabban
Background: Childhood obesity is an important early predictor of adult obesity and associated comorbidities. Common forms of obesity are underpinned by both environmental and genetic factors. However, the rising prevalence of obesity in genetically stable populations strongly suggests that...
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Emerging pathways in the regulation of whole body cholesterol flux: Therapeutic opportunities to target atherosclerosis?
Download2014
Mangat, Rabban, Proctor, Spencer D.
INTRODUCTION: CVD remains one of the most frequent causes of morbidity and mortality globally. Increased awareness of lifestyle factors (nutrition/exercise), as well as the refinement of lipid-lowering therapies, has availed some progress in reducing the incidence of CVD. Historically, the...
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2016-01-01
Bridgman, Sarah L., Konya, Theodore, Azad, Meghan B., Sears, Malcolm R., Becker, A. B., Turvey, Stuart E., Mandhane, P. J., Subbarao, P., Scott, James A., Field, Catherine J., Kozyrskyj, Anita L.
Secretory immunoglobulin A (IgA) plays a critical role in gut mucosal immune defense. Initially provided by breastmilk, IgA production by the infant gut is gradually stimulated by developing gut microbiota. This study reports associations between infant fecal IgA concentrations 4 months after...
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Infant gut microbiota and the hygiene hypothesis of allergic disease: Impact of household pets and siblings on microbiota composition and diversity
Download2013
Field, Catherine J., Guttman, David S., Kozyrskyj, Anita L., Maughan, Heather, Sears, Malcolm R., Konya, Theodore, Scott, James A., Becker, Allan B., Azad, Meghan B.
Background Multiple studies have demonstrated that early-life exposure to pets or siblings affords protection against allergic disease; these associations are commonly attributed to the “hygiene hypothesis”. Recently, low diversity of the infant gut microbiota has also been linked to allergic...
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2014
Bridgman, Sarah L., Letourneau, Nicole, Field, Catherine J., Azad, Meghan B., Johnston, David W., Kozyrskyj, Anita L., Kaplan, Bonnie J.
Background Probiotic products that may modify the intestinal microbiota are becoming increasingly available and known to consumers due to their potential to prevent or treat many pediatric health conditions. As scientific knowledge of the health benefits of probiotics increases, it is important...
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2015
Sopcak, Nicolette, Williamson, Deanna L., Letourneau, Nicole, Stewart, Miriam, Kushner, Kaysi, E., Pitre, Nicole Y., Breitkreuz, Rhonda, Rempel, Gwen
We examined first-time fathers’ and mothers’ perspectives about their ideal world of support in the context of dominant social ideology, ethno-cultural ideals, and the pragmatics of their everyday family, workplace, and socioeconomic circumstances during their first 18 months as parents. Twelve...
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Probiotic supplementation during pregnancy or infancy for the prevention of wheeze and asthma: A systematic review and meta-analysis
Download2013
Ramsey, Clare D., Zarychanski, Ryan , Azad, Meghan B., Coneys, J. Gerard, Friesen, Carol, Becker, Allan B., Abou-Setta, Ahmed M., Field, Catherine J., Kozyrskyj, Anita L.
Objective To evaluate the association of probiotic supplementation during pregnancy or infancy with childhood asthma and wheeze. Design Systematic review and meta-analysis of randomised controlled trials. Data sources Medline, Embase, and Central (Cochrane Library) databases from inception to...