Emerging pathways in the regulation of whole body cholesterol flux: Therapeutic opportunities to target atherosclerosis?

• Author(s) / Creator(s)

  • Mangat, Rabban
  • Proctor, Spencer D.

• INTRODUCTION: CVD remains one of the most frequent causes of morbidity and mortality globally. Increased awareness of lifestyle factors (nutrition/exercise), as well as the refinement of lipid-lowering therapies, has availed some progress in reducing the incidence of CVD. Historically, the hepatic regulation of lipid and cholesterol homeostasis and its contribution to CVD has been the primary focus of research to target lipid-lowering therapy. However, breakthroughs in the understanding of how the intestine complements the liver in whole-body cholesterol homeostasis have provided new advances in our approach to anti-atherosclerotic targets.

• Date created

  2014

• Subjects / Keywords

  • Liver/Metabolism
  • Carrier Proteins/Metabolism
  • Cholesterol/Metabolism
  • Animals
  • Carrier Proteins/Antagonists & Inhibitors

• Type of Item

  Article (Published)

• DOI

  https://doi.org/10.7939/R3XW4891J

• License

  © 2014 by the American Society for Biochemistry and Molecular Biology, Inc.