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Skip to Search Results- 2Herpes simplex virus
- 1Chromatin
- 1Cyclin dependent kinase
- 1Micrococcal nuclease
- 1Pharmacological CDK inhibitors
- 1Roscovitine
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Fall 2010
Herpes Simplex Virus Type 1 (HSV-1) establishes latent infections in neurons in vivo and lytic infections in epithelial cells and fibroblasts. During latent infections, HSV-1 transcription is restricted and the genomes are not replicated. Latent HSV-1 genomes are chromatinized, such that...
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Fall 2014
Viral entry is an attractive antiviral target. Entry inhibitors prevent infection of healthy cells and inhibit viral replication before viruses establish persistent reservoirs. Two entry steps, the primary attachment to cellular glycans and the lipid rearrangements during fusion, are conserved...
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Spring 2011
Transcription and DNA replication of herpes simplex virus type 1 (HSV-1) occur in nuclear domains adjacent to structures named ND10. The HSV-1 single-stranded DNA binding protein ICP8 localizes to these nuclear domains to direct the assembly of the pre- and replication compartments. Inhibition...