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Skip to Search Results- 2Wang, Hui
- 1Boraey, Mohammed A.
- 1Gomez, Mellissa
- 1James Ivey
- 1Karim, Shabab Bin
- 1Molaghasem Shemirani, Farzin
- 3particle engineering
- 3spray drying
- 2shadowgraphic imaging
- 1Aerosol collection
- 1Bulk composition
- 1Co-solvents
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Spring 2014
The process of microparticle formation from evaporating microdroplets is the main production method for many products. For most of these applications (especially pharmaceutical ones) the properties and morphology of the final dry particle have to be precisely tailored to ensure the proper...
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A Particle Engineering Approach to the Development of Microparticles Suitable for Enteric Delivery of Biologics
DownloadFall 2021
Despite tremendous advances in the field of medical science, enteric infections still account for millions of deaths globally each year. Inaccessibility to clean drinking water, sanitation systems and proper healthcare infrastructure in developing parts of the world remains a huge obstacle to...
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Assessing Colloidal Stability of Pharmaceutical Suspensions with a Shadowgraphic Imaging Method
DownloadFall 2019
The colloidal stability of pharmaceutical suspensions is an important attribute that needs to be carefully characterized in order to ensure designed product quality. In the field of respiratory drug delivery, pharmaceutical suspensions contained in pressurized metered-dose inhalers (pMDIs) are...
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Development of a Thermostable Tuberculosis Vaccine Candidate Suitable for Pulmonary Delivery through Particle Engineering
DownloadFall 2020
Tuberculosis (TB) is a preventable and curable highly infectious respiratory disease that is responsible for the deaths of approximately 1.5 million people every year. However, vaccination programs are hindered by refrigeration requirements for vaccines during transportation and storage....
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Fall 2021
In this thesis, several fundamental studies were conducted to tackle some of the unanswered questions in the design and engineering of inhalable microparticles produced via spray drying. Different experimental and theoretical methods were applied to understand the mechanisms that control particle...
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Investigations in Formation and Properties of Spray-Dried Microparticles using Monodisperse Spray Drying
DownloadSpring 2021
The scaling up of monodisperse spray drying and the formation and properties of several spray-dried particle systems are investigated in this thesis. First, gallium focused ion beam milling was used to manufacture multi-orifice plates installed in a vibrating orifice atomizer in order to increase...
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Low-frequency and macro-Raman analysis of respirable dosage forms and their sampling with a low flow rate single-nozzle cascade impactor
DownloadSpring 2015
Applications of Raman spectroscopy to respirable dosage forms are explored in this thesis. First, a high performance Raman system enabling low-frequency Raman signal detection is described and used for pharmaceutical sample analysis. Applications to species identification and solid state...
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Spring 2015
The current work focuses on three different aspects of the aerosols involved in Metered Dose Inhaler (MDI) sprays. The efficiency of the drug delivery in different ambient conditions, production of monodisperse solid particles to study the heat and mass transfer processes involved, and study of...
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Fall 2018
This thesis is concerned with the mechanisms by which evaporating droplets containing dissolved or suspended solids transform into dry particles, and emphasizes applied research in the area of inhaled drug delivery. The main focus is on understanding and quantifying the relationships between the...
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Spring 2013
Shamsaddini Shahrbabak, Abouzar
A thorough understanding and precise characterization of powdered excipients and drugs are of great importance to enhance the quality of the final product. Powder compression is a common method to evaluate their properties and behavior. It is essential to understand the elastic, viscoelastic and...