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2003

Chan, Catherine B., Wang, Xiaolin, Koshkin, Vasilij, Wheeler, Michael B., Scherer, Philipp E.

Excessive free fatty acid (FFA) exposure represents a potentially important diabetogenic condition that can impair insulin secretion from pancreatic β-cells. Because mitochondrial oxidative phosphorylation is a main link between glucose metabolism and insulin secretion, in the present work we...

2014

McBride, Ryan, Fokin, Valery V., He, Yuan, Macauley, Matthew S., Paulson, James C. , Arlian, Britni M., Rillahan, Cory D., Rangarajan, Janani, Schwartz, Erik

The siglec family of sialic acid-binding proteins are endocytic immune cell receptors that are recognized as potential targets for cell directed therapies. CD33 and CD22 are prototypical members and are validated candidates for targeting acute myeloid leukaemia and non-Hodgkin's lymphomas due to...

2009

Assis, Leandro C.S., Brigandt, Ingo

Taxa and homologues can in our view be construed both as kinds and as individuals. However, the conceptualization of taxa as natural kinds in the sense of homeostatic property cluster kinds has been criticized by some systematists, as it seems that even such kinds cannot evolve due to their being...

2008

Rankin, Robert, Degeling, Alex W.

The interaction between relativistic, equatorially mirroring electrons and Pc5 Ultra Low Frequency (ULF) waves in the magnetosphere is investigated using a numerical MagnetoHydroDynamic (MHD) model for waves and a test-kinetic model for electron phase space density (PSD). The temporal and spatial...

1996

Jones, S. D. M., Price, M. A., Coupland, T., Robertson, W. M.

A total of 281 lamb carcasses covering three weight groups (18–22.9, 23–25.9 and 26–30 kg) and fatness (< 3 mm, 3–5 mm and > 5 mm) were used to determine the usefulness of several carcass measurements for predicting saleable meat yield. Carcasses were measured for fat and muscle depth, 3–4 cm...

2016

Kitova, Elena N., Klassen, John S., Eugenio, Luiz, Li, Jun, Ng, Kenneth, Zhang, Jingjing

The application of hydrogen/deuterium exchange mass spectrometry (HDX-MS) to localize ligand binding sites in carbohydrate-binding proteins is described. Proteins from three bacterial toxins, the B subunit homopentamers of Cholera toxin and Shiga toxin type 1 and a fragment of Clostridium...

2004

Manchak, J., Hayakawa, K., Audette, G.F., Holland, S.J., Frost, L.S., Hazes, B.

TraF, a component of the Escherichia coli type IV secretory system, has been crystallized and preliminary X-ray diffraction data have been collected. TraF is a 26 kDa protein encoded by the E. coli F plasmid and is required for conjugative plasmid transfer and the formation of sex pili. The...

4/18/2013

Encarnação, P., Alvarez, L., Maya, C., Cook, A. M., Adams, K., L., Rios

2013

Comeau, T., Newburn-Cook, C., Lasiuk, G. C., , &

Background Preterm birth (PTB) places a considerable emotional, psychological, and financial burden on parents, families, health care resources, and society as a whole. Efforts to estimate these costs have typically considered the direct medical costs of the initial hospital and outpatient...

2014

Mansoor Nadia, Vandermeer Ben, Bassler Dirk, Kumar Manoj

Objective: To assess evidence from randomized controlled trials (RCTs) about the efficacy of low-dose heparin for prolonging patency of peripheral intravenous catheters in adults. Design: Systematic review and meta-analysis. Data Sources: We searched MEDLINE, EMBASE, CINAHL and Cochrane Central...