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Analytical and Toxicological Characterization of Novel Nitrogen Containing Disinfection Byproducts
DownloadFall 2012
Disinfection byproducts (DBPs) are an unwanted consequence of water disinfection. Consumption of chlorinated drinking water has been associated with an increased risk of bladder cancer; however, the DBP or DBPs responsible has not been identified. The N-nitrosamines are a class of DBPs that are...
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Cell-electronic Sensing of Cellular Responses and Toxicity Induced by Nanoparticles and Arsenic Species
DownloadFall 2013
We demonstrate the development of a real-time cell analysis (RTCA) platform for studying nanoparticle- and arsenic-induced cytotoxicity with potential applications to risk assessment, environmental toxicity monitoring, and drug development. RTCA is an impedance-based in vitro detection system...
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Cytotoxicity, mutagenicity, and genotoxicity of emerging drinking water disinfection byproducts
DownloadSpring 2014
Drinking water disinfection byproducts (DBPs) are formed unintentionally when organic matter in raw water reacts with disinfectants used to kill pathogens. Epidemiological studies have shown that an increased risk of bladder cancer is associated with consumption of chlorinated water, but little...
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Spring 2014
Benzo[a]pyrene diol epoxide (BPDE), a known carcinogen, is a reactive metabolite of benzo[a]pyrene (BP). BP is usually formed during combustion of organic substances, such as cigarette smoke, automobile emission exhaust, and industrial waste burning. BPDE can covalently bind to the nucleobases of...
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Spring 2013
Binding-induced DNA assembly (BINDA) was initially developed for protein detection. To demonstrate the homogeneous detection of carbohydrates using this principle, a BINDA assay for the pancreatic cancer marker carbohydrate antigen 19-9 (CA 19-9) was developed. The assay uses two DNA- antibody...