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Skip to Search Results- 1Abuetabh, Yasser H
- 1Albahrani, Redha Mohammed
- 1Allen,Richelle J
- 1Almizraq, Ruqayyah J
- 1Bahitham, Wesam Ahmad
- 1Beesoon,Sanjay
- 5Li, Xing-Fang (Laboratory Medicine and Pathology)
- 2Acker, Jason (Laboratory Medicine and Pathology)
- 2Lai, Raymond (Laboratory Medicine and Pathology)
- 2Le, X. Chris (Laboratory Medicine and Pathology)
- 2Sergi, Consolato (Department of Laboratory Medicine and Pathology and Department of Pediatrics)
- 1Acker, Jason (Supervisor, Department of Laboratory Medicine and Pathology)
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A novel mouse model of acute antibody-mediated transplant rejection shows simultaneous complement activating and anti-inflammatory effects of donor specific IgG antibodies
DownloadFall 2013
We developed a small animal model of pure antibody-mediated rejection (ABMR) by utilizing fully major histocompatibility complex (MHC) mismatched kidney allografts in mice. By examining resultant ABMR pathology, we show that terminal complement products C5a and C5b-9 are crucial in establishing...
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Analytical and Toxicological Characterization of Novel Nitrogen Containing Disinfection Byproducts
DownloadFall 2012
Disinfection byproducts (DBPs) are an unwanted consequence of water disinfection. Consumption of chlorinated drinking water has been associated with an increased risk of bladder cancer; however, the DBP or DBPs responsible has not been identified. The N-nitrosamines are a class of DBPs that are...
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Fall 2009
First-line treatment of breast and other cancers with Taxol is compromised by resistance in up to 40% of patients. To improve chemotherapy, it is vital to understand how Taxol resistance develops and to overcome this. Autotaxin (ATX) promotes cancer cell survival, growth, migration, invasion...
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Cell-electronic Sensing of Cellular Responses and Toxicity Induced by Nanoparticles and Arsenic Species
DownloadFall 2013
We demonstrate the development of a real-time cell analysis (RTCA) platform for studying nanoparticle- and arsenic-induced cytotoxicity with potential applications to risk assessment, environmental toxicity monitoring, and drug development. RTCA is an impedance-based in vitro detection system...
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Fall 2009
Recent advances in the fundamental theories in cryobiology using thermodynamic principles have created new opportunities for innovative methodologies in cryobiology. This thesis tested the hypothesis that calculated indicators of the two-factor hypothesis of cryoinjury, depending on cellular...
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Characterization of Phosphoglycerate Kinase Expressed on the Surface of Group B Streptococcus
DownloadSpring 2012
Group B streptococcus (GBS) is a major cause of invasive disease in the neonatal and adult populations. To mediate invasive disease, GBS encodes a variety of surface expressed and secreted components. One surface expressed protein that may contribute to GBS virulence is phosphoglycerate kinase...
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Spring 2013
There has been significant interest in the literature on the possibility of using red blood cells (RBCs) derived from umbilical cord blood (cord RBCs) for neonatal transfusions. Low stability of cord RBCs during hypothermic storage necessitates the development of a cryopreservation method to...
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Cytotoxicity, mutagenicity, and genotoxicity of emerging drinking water disinfection byproducts
DownloadSpring 2014
Drinking water disinfection byproducts (DBPs) are formed unintentionally when organic matter in raw water reacts with disinfectants used to kill pathogens. Epidemiological studies have shown that an increased risk of bladder cancer is associated with consumption of chlorinated water, but little...
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Spring 2013
Chavali Venkata Subramanya, Ravi Shankar
The In-gel polymerase chain reaction (PCR) technology developed by our group at the University of Alberta makes use of PCR reagents entrapped within nano-liter polyacrylamide gels. To adapt this technology for use at the point of care, methods were developed to preserve gel-based PCR reagents by...
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Spring 2014
Benzo[a]pyrene diol epoxide (BPDE), a known carcinogen, is a reactive metabolite of benzo[a]pyrene (BP). BP is usually formed during combustion of organic substances, such as cigarette smoke, automobile emission exhaust, and industrial waste burning. BPDE can covalently bind to the nucleobases of...