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Skip to Search Results- 2Sigalet, David L.
- 2Yamoah, Ebenezer Nketia.
- 1Aboelnazar, Nader Saber
- 1Abualhassan, Nasser
- 1Adegoke, Adeolu
- 1Aggarwal, Saloni
- 7Mesenchymal stem cells
- 7Scars
- 6Diabetes
- 6Islet transplantation
- 5Cerebrovascular spasm--Animal models
- 5Fibroblasts
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New Insights into the Mechanisms of Vascular Dysfunction in a Young and Aged Septic Murine Model
DownloadFall 2022
Background: Sepsis is a dysregulated response to infection that results in life-threatening organ dysfunction. The elderly are disproportionately affected by sepsis and suffer an alarmingly high mortality rate. We hypothesized that increased mortality in the aged is due to a more highly...
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Novel Mediators and Medical Prevention of Bladder Fibrosis After Partial Bladder Outlet Obstruction
DownloadFall 2012
Introduction: Partial bladder outlet obstruction (pBOO) is a significant problem that can affect renal health. We hypothesize that changes occur in small leucine-rich proteoglycan (SLRP) composition of extracellular matrix over time in this process. We hypothesize that medical treatment of...
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Fall 2009
Islet transplantation is an attractive method to achieve blood glucose homeostasis. However, β-cell function declines over time. Therefore, it is necessary to explore strategies to enhance the β-cell mass and function. Also, because there is a severe shortage of human cadaver tissue, alternative...
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Fall 2015
Osteoarthritis, a disease resulting in the breakdown of cartilage and bone within joints, is a global burden that is growing in scope. There is no cure for osteoarthritis, and the current treatments are all lacking in some form or another. One treatment which attempts to prevent degeneration of...
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Fall 2011
In-vitro expansion of the duct cells of the pancreas was associated with loss of the epithelial phenotype of these cells and acquisition of mesenchymal phenotype. These changes have been explained by epithelial mesenchymal transition. We have tested the effect of several growth factors that have...
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Optimizing impermeant support in an intraluminal preservation solution tailored to the small intestine
DownloadFall 2012
The AA (amino acid) solution is an experimental preservation solution delivered intraluminally and tailored to the metabolic requirements of the small bowel. Preservation solutions contain impermeant molecules to prevent edema formation. Dextrans and hydroxyethylstarches are two such oncotic...
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Fall 2022
Marfil Garza, Braulio Alejandro
Type 1 diabetes (T1D) is caused by autoimmune-mediated destruction of the insulin-producing β-cells in the pancreatic islets of Langerhans. People with T1D need exogenous insulin to survive, but also to avoid complications from uncontrolled glycemia. Unfortunately, insulin treatment commonly...