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Skip to Search Results- 2Hegadoren, Kathleen M.
- 1Adu, Medard Kofi
- 1Al-Ghamdi,Mohammad S
- 1Al-Nuaimi, Saleem K
- 1Amritraj, Asha
- 1Amusan, Precious
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Putative ante-mortem indicators of Alzheimer’s dementia: Analysis of fluid biomarker and neuroimaging studies
DownloadSpring 2019
Dementia is a clinical state, characterized by symptoms indicative of deterioration of memoryand cognitive functions that interferes with social or occupational functioning. According to2018 statistics, around 50 million people are living with dementia, and this number will increaseto 131.5...
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Fall 2019
Stories matter deeply. They help us see, experience, understand, and make meaning in our world and lives. As we will see in this dissertation, to create lasting positive social change, we need new stories, stories that reveal new paths, hopes, and futures. Art is a powerful storytelling medium,...
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Computational psychiatry: machine learning for clinical decision support in the treatment of major depression
DownloadFall 2019
The goal of this thesis is to contribute to the fields of data-driven medicine and computational psychiatry by attempting to demonstrate the viability of machine learning for use in psychiatry, specifically in predicting treatment outcomes for major depression. This is attempted in four ways: ...
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Spring 2018
Patients who have a severe mental illness such as psychosis experience a greater burden in terms of poor physical and mental health outcomes or adverse health outcome/s (AHO). The etiological factors for AHO include the illness itself, medication side effects, poor diet and lifestyle, substance...
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Rapid effectiveness of intravenous ketamine for ultraresistant depression in a clinical setting and evidence for baseline anhedonia and bipolarity as clinical predictors of effectiveness
DownloadFall 2018
Background Intravenous ketamine has been established as an efficacious and safe treatment, with transient effect, for treatment-resistant depression. However, the effectiveness of intravenous ketamine in non-research settings and with ultraresistant depression patients remains...
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Spring 2017
Neurocysticercosis, the major global cause of acquired epilepsy, is a parasitic disease caused by Taenia solium larvae. Patients may have seizures whether larvae in brain are alive or degenerated (calcified). We assessed whether parasitic lesions produce changes in structural brain scans that are...
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Spring 2017
The purpose of this study was to contribute to research on group cohesion among patients attending treatment for their substance abuse. Participants (N = 102) were recruited from a residential substance abuse treatment facility and assessed for group cohesion using the Group Climate Questionnaire...
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The role of β-amyloid peptides in kainic acid-induced toxicity and its implications in Mesial Temporal Lobe Epilepsy
DownloadFall 2017
Kainic acid is a non-degradable analogue of the excitatory neurotransmitter glutamate that, when injected systemically into adult rats, can trigger seizures and progressive neuronal loss in a manner that mirrors the neuropathology of human mesial temporal lobe epilepsy (MTLE), most prevalent form...
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Possible effectiveness of a novel multimodal school-based program, EMPATHY, to reduce substance misuse in youth: A mixed methods intervention
DownloadSpring 2017
Substance misuse in Canada is a major individual and public health issue, with evidence suggesting that in many cases it starts during youth. Reducing rates of misuse is therefore important. In 2013, an estimated 3.1 million Canadians over the age of 15 used at least one of 6 illicit substances...