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- 2Coulombe, Marilyne G.
- 2Logus, J. Wayne (John Wayne), 1951-
- 1Abdualla, Radya Y
- 1Abofayed, Hiatem Abdullah
- 1Agrawal, Amogh
- 1Ahmed, Iqbal Hussein, 1953-
- 7Primary Biliary Cholangitis
- 6Inflammatory bowel disease
- 5Inflammatory Bowel Disease
- 4B cells
- 4Endothelial cells
All mammalian cells rely on adenosine triphosphate (ATP) to maintain function and for survival. The heart has the highest basal ATP demand of any organ due to the necessity for continuous contraction. As such, the ability of the cardiomyocyte to monitor cellular energy status and adapt the supply...
Community-Driven Research in the Canadian Arctic: Investigating the Effect of Dietary Exposure to Methylmercury on the Severity of Chronic Inflammation and Gastric Neoplasia in Populations with an Elevated Risk of Gastric CancerDownload
Introduction While gastric cancer has been declining in incidence for decades globally, it remains a major cause of death. Evidence suggests that Indigenous populations worldwide experience a higher burden of gastric cancer relative to non-Indigenous populations residing in the same geographic...
The Role of Vitamin D in Anti-Tumor Necrosis Factor-Alpha-Induced Response in Patients with Inflammatory Bowel DiseaseDownload
Vitamin D is an important immunomodulator of the immune system and has been suggested to play a role in the pathogenesis of inflammatory bowel disease (IBD). Drugs targeting TNF-alpha are effective IBD therapies, and vitamin D has been demonstrated to suppress TNF-alpha as well as work...
The Detection of Antibodies against Human Betaretrovirus Surface Protein in Patients with Primary Biliary CirrhosisDownload
Introduction: Primary biliary cirrhosis is an autoimmune liver disease in which cellular and humoral immune responses towards cholangiocytes cause progressive intrahepatic bile duct loss. Cholestasis, liver fibrosis, and eventually cirrhosis result, with liver transplantation or death occurring...
Epidemiologic Risk Factors of Antimicrobial Resistance in Patients with Septic Shock Admitted to North American Critical Care Units: A Retrospective StudyDownload
INTRODUCTION: Antibiotic resistance is a serious global threat resulting in a significant clinical and economic burden. The cost of caring for patients with resistant infections is high ($6,000-$30,000 USD 2008). The examination of resistance between different epidemiological groups is required...
Anti-TNF therapy is effective for the induction and maintenance of remission in patients with inflammatory bowel disease (IBD). The benefits of anti-TNF therapy include improved quality of life, steroid discontinuation, and reduced hospitalization and surgery rates. Due to their high costs and...
Research is crucial for the development of treatment guidelines. Informed consent is an essential component to ensure the ethical integrity of research. An ideal informed consent should meet three requirements; disclosure of adequate information about the study, subjects understand the...
Comparing contact investigations of tuberculosis cases among the Canadian Born Aboriginal and non-Aboriginal population in Alberta, CanadaDownload
It is well established that the rates of tuberculosis (TB) among Aboriginal Peoples in Alberta are disproportionately higher than those in the Canadian-born 'other' population group (Jensen, Lau, Langlois-Klassen, et al., 2012). In addition, Aboriginal Peoples living on-reserve have higher rates...