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Influenza Vaccination in Solid Organ Tranplant Recipients

  • Author / Creator
    Baluch, Aliyah
  • Immunogenicity of intramuscular influenza vaccine is suboptimal in organ transplant recipients although intradermal vaccine may be superior by targeting dermal dendritic cells to stimulate a response. 229 patients were randomized to IM or high-dose ID vaccine during the 2010-11 season. Pre- and 1 month post-vaccine bloodwork measured serology by hemagglutination inhibition assay (for influenza A/H1N1, A/H3N2 and B strains) and HLA antibody. Seroconversion was defined as a 4-fold rise in titer. Median time from transplant was 4.9 years. In 212 evaluable patients (105 IM, 107 ID), seroconversion to at least one antigen was 46.7% & 51.4% respectively (p=0.5). Seroconversion to at least 1 antigen was greater if i) ≥ 6 months post-transplant (53.2% vs. 19.2%; p=0.001) or ii) on <2g of mycophenolate mofetil (60.0% vs. 36.7%; p=0.001). Our study suggests that intradermal vaccine is safe, may be more immunogenic in selected subgroups and does not increase clinically relevant HLA antibody.

  • Subjects / Keywords
  • Graduation date
    2013-06
  • Type of Item
    Thesis
  • Degree
    Master of Science
  • DOI
    https://doi.org/10.7939/R31S6C
  • License
    This thesis is made available by the University of Alberta Libraries with permission of the copyright owner solely for non-commercial purposes. This thesis, or any portion thereof, may not otherwise be copied or reproduced without the written consent of the copyright owner, except to the extent permitted by Canadian copyright law.
  • Language
    English
  • Institution
    University of Alberta
  • Degree level
    Master's
  • Department
    • Department of Medicine
  • Specialization
    • Experimental Medicine
  • Supervisor / co-supervisor and their department(s)
    • Deepali Kumar, MD (Transplant Infectious Diseases)
  • Examining committee members and their departments
    • Atul Humar, MD (Transplant Inectious Diseases)
    • Simon Urschel, MD (Pediatric Transplant Cardiology)
    • Patricia Campbell, MD (Transplant Nephrology)