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- 2Li, Leo
- 2Nizio, Katie D
- 1Abdel Latif Ibraheem, Ahmed Abdel Mohsen
- 1Abdelfattah, Ahmed
- 1Abel, Robin Jacob
- 1Abou-Ghanem, Maya
- 23Organic compounds. Synthesis.
- 21Capillary electrophoresis.
- 18Chemical reactions.
Transition-metal catalyzed cross-coupling reactions are a broad set of tools that enable the generation of molecular complexity by coupling together molecular pieces. This is done by the use of activating groups on the molecular pieces and a metal-based catalyst. These methods are widely used in...
Synthetic Studies on Novel Facially Amphiphilic Sesquiterpenoid- and 11β-Steroid-Amino Acid Conjugates and Transition Metal Mediated Steroid-Amino Acid Derived BiometallosurfactantsDownload
Sesquiterpenoid- and steroid-amino acid conjugates demonstrate a broad array of interesting biological properties, as the different segments of the conjugate function collectively to regulate conformation, recognition, transport and solubility. The current project involved developing a facile...
Investigating Protein-Carbohydrate Interactions with Hydrogen/Deuterium Exchange Mass Spectrometry (HDX-MS)Download
The application of hydrogen/deuterium exchange mass spectrometry (HDX-MS) to investigating protein-carbohydrate interactions is described. Proteins from three bacterial toxins, the B subunit homopentamers of Cholera toxin (CTB5) and Shiga toxin type 1 (Stx1B5) and a fragment of Clostridium...
The most prevalent oxidation states of vanadium in nature are V(IV) and V(V). Toxicity of vanadium increases with increasing oxidation state. A high-performance-liquid-chromatography inductively-coupled-plasma mass-spectrometry method was optimized for the speciation of V(IV) and V(V). It was...
Solid-State Nuclear Magnetic Resonance and Computational Investigation of Half-integer Quadrupolar NucleiDownload
This thesis is concerned with applications of modern solid-state NMR spectroscopy. Investigations of three quadrupolar nuclei (51V, 17O, and 23Na) are undertaken to demonstrate the practicality of solid-state nuclear magnetic resonance, SSNMR in studies of compounds containing these nuclei. The...