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Skip to Search Results- 20Graduate and Postdoctoral Studies (GPS), Faculty of
- 20Graduate and Postdoctoral Studies (GPS), Faculty of /Theses and Dissertations
- 4Agricultural, Food and Nutritional Science, Department of
- 4Agricultural, Food and Nutritional Science, Department of/Journal Articles (Agricultural, Food and Nutritional Science)
- 3Biological Sciences, Department of
- 3Biological Sciences, Department of/Journal Articles (Biological Sciences)
- 5Centre for Neuroscience
- 3Department of Pharmacology
- 3Department of Physiology
- 2Department of Biological Sciences
- 2Neuroscience
- 1Department of Agricultural, Food, and Nutritional Science
- 2Tse, Amy (Centre for Neuroscience and Department of Pharmacology)
- 1Ali, Declan (Biological Sciences)
- 1Ballanyi, Klaus (Physiology Department, University of Alberta)
- 1Chen, Xing-Zhen (Physiology)
- 1Clayton T. Dickson (Psychology, Physiology, Anesthesia and Pain Medicine, Neuroscience and Mental Health Institute)
- 1Colmers, William F. (Pharmacology)
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Emerging pathways in the regulation of whole body cholesterol flux: Therapeutic opportunities to target atherosclerosis?
Download2014
Mangat, Rabban, Proctor, Spencer D.
INTRODUCTION: CVD remains one of the most frequent causes of morbidity and mortality globally. Increased awareness of lifestyle factors (nutrition/exercise), as well as the refinement of lipid-lowering therapies, has availed some progress in reducing the incidence of CVD. Historically, the...
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The Expression of Transmembrane AMPA Receptor Regulatory Proteins (TARPs) in Developing Zebrafish (Danio rerio)
DownloadFall 2013
In embryonic vertebrates, newly-formed synapses are quiet until they are unsilenced through a process that resembles synaptic plasticity but remains mechanistically unclear. I used gene expression to determine if Transmembrane AMPA Receptor Regulatory Proteins (TARPs), AMPA receptor auxiliary...
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Regulation of Cardiac Gap Junctional Communication: Metabolic regulation of Cx40 and Cx43 via phosphorylation
DownloadFall 2015
Alterations in myocardial metabolism and cardiac electrophysiology associated with structural heart disease generate lethal arrhythmias. Differential levels of energy (ATP) supply and demand are generated with structural heart disease that is expected to activate 5’-amp activated protein kinase...
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Fall 2015
Polycystic kidney disease (PKD) protein 2 Like 1 (PKD2L1), also called transient receptor potential polycystin-3 (TRPP3), regulates Ca2+-dependent hedgehog signalling in primary cilia, intestinal development and sour tasting but with an unclear mechanism. PKD2L1 is a Ca2+-permeable cation channel...
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Spring 2012
Neuropathic pain afflicts 1.5-3% of the general population. It can be initiated by traumatic nerve injuries or diseases such as diabetic or post-herpetic neuropathy. Neuropathic pain is often initiated by abnormal spontaneous activity in sensory neurons and this provokes increased excitability of...
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Pharmacological and Fluorometric Assessment of Neuronal KCNQ Channels, and Implications for Understanding Neurological Disease
DownloadSpring 2020
Epilepsy affects 60 million people worldwide, and encompasses the most common forms of neurological disorders. Epilepsy manifests in diverse ways in patients, ranging from mild cognitive effects, to seizures, to the more severe epileptic encephalopathy. While many pharmacological approaches exist...
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2014
Conroy, Sherrill A., Murray, Cynthia L.
Low maternal, gestational weight gain is associated with preterm birth, intrauterine growth restriction, low birthweight, small-for-gestational-age infants, neural tube defects, infant death, failure to initiate breastfeeding, and childhood asthma. The advantage of qualitative research is it can...
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Spring 2016
This thesis examines the cellular basis of the acute (<1 hour) anti-allodynic actions of the clinically-approved neuropathic pain drug gabapentin (GBP) in rats at the level of the spinal dorsal horn and primary somatosensory cortex. Although the clinical effectiveness of the alpha-2-delta (α2δ)...
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Spring 2014
Modifiable cardiovascular disease (CVD) risk factors, such as adiposity, are already associated with atherosclerotic progression in childhood. Less is known about whether physical activity (PA) is associated with progression of atherosclerosis in non-clinical samples of children. This...
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Fall 2015
Nucleosides are essential for RNA and DNA synthesis. They also play a central role in other cellular metabolic pathways, and modulate a diverse array of physiological processes, including renal and cardiovascular function and neurotransmission. Due to their hydrophilic nature, specialized...