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Skip to Search Results- 1Allison, W. T.
- 1Andres, Alexis D
- 1Casey, Geoffrey A
- 1Cheng, Caroline ST
- 1Crichton,Paul
- 1Erickson, Timothy
- 2Waskiewicz, Andrew (Biological Sciences)
- 1Allison, Ted (Biological Sciences)
- 1Allison, W. Ted (Biological Sciences, Medical Genetics)
- 1Andrew Waskiewicz, Biological Sciences
- 1Barreda, Daniel (Biological Sciences)
- 1Dr. Andrew Waskiewicz (Department of Biological Sciences, University of Alberta)
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Patterning the zebrafish visual system requires the actions of Pbx transcription factors, and a downstream growth factor, Gdf6a
DownloadFall 2010
The zebrafish visual system relies on positional information in the retina and optic tectum, so that the spatial fidelity of light signals that enter the eye are preserved for visual processing. This positional information is essential for ordered topographic mapping of retinal ganglion cell...
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Fall 2012
Sensory systems are complex structures that receive stimuli from the surrounding environment and convert them into interpretable information. In the visual system, light hitting the eye is transmitted to the brain in a way that preserves the spatial conformation of the pictures we see. Retinal...
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Fall 2012
Teleosts rely on innate immunity to protect themselves from pathogens. Colony stimulating factor-1 (CSF-1) and its cognate receptor CSF-1R control survival, proliferation, differentiation and function of macrophages. Recently, a novel soluble form of CSF-1R (sCSF-1R) was identified in goldfish....
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Fall 2017
Development of the vertebrate ocular structures requires the cooperative interactions of transcription factors, signalling proteins, external growth factors, and epigenetic regulatory factors. Consequently, misregulation of these cues can result in a number of developmental and functional...
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Examination of channel catfish (Ictalurus punctatus) leukocyte immune-type receptor-mediated crosstalk regulation of phagocytosis
DownloadFall 2020
Across vertebrates, innate immune cells are capable of initiating a range of potent effector responses that are designed to destroy or contain foreign microbial invaders. The execution and regulation of various innate cellular responses is mediated by a dedicated repertoire of cell...
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The roles of Pbx and Meis TALE-class homeodomain transcription factors in vertebrate neural patterning
DownloadFall 2010
One of the major goals of developmental biology is to understand how specialized groups of cells arise from an initially unspecified cell population. The vertebrate hindbrain is transiently segmented along its anterior-posterior axis into lineage-restricted compartments called rhombomeres, making...
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Innate Immunity and the Retinal Pigment Epithelium in Gene Therapy for Inherited Retinal Disorders
DownloadFall 2021
Background: The photoreceptors are post-mitotic (no longer dividing), so the eye has evolved several unique immunological mechanisms to protect the photoreceptors and prevent vision loss. Inherited retinal disorders occur when mutations disrupt normal retinal function and photoreceptors die....
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Creation of an in-vitro¬ Co-culture Model of Microglia and Retinal Pigment Epithelium Cells for Investigating the Innate Immune Mechanisms of the Retina
DownloadFall 2022
Background: The immune mechanisms of the retina in response to gene therapy have been previously understudied due to assumptions of ocular immune privilege. Ocular immune privilege is the concept that there is a tolerance or reduced immune response to antigen exposure in the eye. With the recent...
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Visual pigment composition in zebrafish: Evidence for a rhodopsin-porphyropsin interchange system
Download2004
Temple, S. E., Allison, W. T., Haimberger, T. J., Hawryshyn, C. W.
Abstract: Numerous reports have concluded that zebrafish (Danio rerio) possesses A(1)-based visual pigments in their rod and cone photoreceptors. In the present study, we investigated the possibility that zebrafish have a paired visual pigment system. We measured the spectral absorption...