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Skip to Search Results- 1Abdulsalam Alharbi
- 1Aktary, Zackie M
- 1Alolayan, Waad Riyad
- 1Alshamsan, Aws
- 1Amritpal Singh Bhullar
- 1Armanious, Hanan A R
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Versatile Polymer-Based Nanomedicines for Drug/Gene Delivery and Cell-based Therapy Applications
DownloadSpring 2021
Advances in polymer science and nanotechnology have allowed the development of biomaterials for cell-based applications, such as the delivery of a variety of drugs and genes, as well as supporting technologies, such as stem cell therapies, tissue engineering and cryopreservation. The progress in...
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Towards superior cancer drugs by modeling approaches: Modification and prediction of the mode of action
DownloadFall 2021
Cancer is a leading cause of death that imposes significant economic and social suffering on a global scale. Based on the projected growth and ageing of populations, the global burden of cancer is set to increase. Despite the vast investment in cancer research, the rate of translation of research...
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Fall 2020
Around the world, cancer is a leading cause of death and the burden of cancer is expected to increase in low-and middle-income countries (LMICs), where 82% of the world’s population resides. In these countries, which include Pakistan, aspects of the culture and traditions, inaccessibility to...
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Development of Novel Polymeric Micellar DACHPt for Enhanced Platinum Based Chemotherapy in Colorectal Cancer
DownloadSpring 2019
One of the major limitations of chemotherapy in cancer treatment is the side effects of anti-cancer drugs. This happens due to non-selective distribution of most standard chemotherapies, and their action on cancer and all normal dividing cells. The objective of this project is to develop a novel...
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The effect of eicosapentaenoic and docosahexaenoic fatty acids on body composition and response to chemotherapy in patients with lung cancer
DownloadFall 2011
Patients with lung cancer are at high risk for malnutrition and even mild weight loss has been associated with decreased median survival and poor response to chemotherapy. The purpose of this research was to describe fatty acids status during chemotherapy and determine if supplementation with...
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Food intake behaviour in advanced cancer – implications of taste and smell alterations, orosensory reward, and cannabinoid therapy
DownloadFall 2009
Food intake is regulated by both appetite and orosensory reward systems. Appetite systems stimulate or reduce hunger, while orosensory reward motivates consumption of high fat sweet foods, resulting in food enjoyment. The majority of advanced cancer patients suffer from malnutrition and wasting,...
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Fall 2013
Plakoglobin (γ-catenin) is a member of the Armadillo family of proteins and a homolog of β-catenin with similar dual adhesive and signaling functions. The adhesive function of these proteins is mediated by their interactions with cadherins and their signaling function by association with various...
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Spring 2015
The tumor suppressor protein Ras association domain family 1A (RASSF1A) has roles in multiple signaling pathways including modulating apoptosis, the cell cycle, DNA damage, and microtubule organization. RASSF1A has been shown to be one of the most frequently epigenetically silenced genes in a...
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Anti-Cancer Mechanism of Trastuzumab via Blocking Nuclear HER2 Function and Epigenetic Mechanism of Resistance
DownloadSpring 2020
HER2 receptor tyrosine kinase (encoded by ERBB2 gene) is overexpressed in approximately 25% of all breast cancer tumors (known as HER2-positive breast cancers). Overexpression of HER2 causes overactivation of downstream receptor tyrosine kinase pathways including PI3K/Akt and MAPK pathways and is...
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Evaluation of Hypoxia Induced Regulation of Nucleoside and Amino Acid Membrane Transporters in Breast Cancer
DownloadSpring 2020
Positron Emission Tomography (PET) utilizes radioactively tagged molecules to identify cancerous tissue. In most cases, membrane transporters control entry of these molecules into human cancer cells. Hypoxia-inducible factor (HIF)-1 is the master homeostatic regulator during hypoxia in human...