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Skip to Search Results- 2Veldhoen, Richard
- 1Abdelrahman, Ali Satti Abdellatif
- 1Abdualmjid,Reem J
- 1Abdurrahim, Amna E.
- 1Araya, Luam Ellen
- 1Baghdasarian, Argishti
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Investigation of BCL-2 interacting killer (BIK) as a breast cancer biomarker and its role in failed apoptosis
DownloadSpring 2019
Breast cancer is the number one cause of cancer-associated deaths in women worldwide. It can be broadly classified into estrogen receptor (ER) positive or -negative subtypes which form the basis of treatment. Despite the therapeutic advancements, more than half a million women annually succumb to...
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Turbidity Mitigation in an Oil Sands End Pit Lake through pH Reduction and Fresh Water Addition
DownloadFall 2016
The remediation of oil sands wastes such as fluid fine tailings (FFT) and oil sands process-affected water (OSPW) are of increasing concern in the oil sands industry. End pit lakes are one remediation option currently being researched at commercial scale in Base Mine Lake (BML) operated by...
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Biological Treatment of Naphthenic Acids and Other Organic Compounds in Oil Sands Process-Affected Waters
DownloadFall 2014
The Alberta oil sands contain one of the world’s largest reserves of oil - over 169 billion barrels of bitumen are economically recoverable with current extraction technologies. Surface mining, whereby the ore is extricated from the earth and bitumen is obtained via a hot water extraction...
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Mitochondrial Dysfunction and Induction of Apoptosis in Hepatocellular Carcinoma and Cholangiocarcinoma Cell Lines by Thymoquinone
DownloadSpring 2015
Thymoquinone, the plant-based bioactive constituent derived from the volatile oil of Nigella sativa, has been shown to possess considerable anti-neoplastic activity. The present study aimed to investigate the anti-tumour property of TQ against hepatocellular carcinoma (HepG2) and...
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The Role of Forkhead Box Transcription Factors in Zebrafish Ocular Development and the Superior Ocular Fissure
DownloadFall 2014
Ocular development is a tightly orchestrated process that is dependent upon precise environmental and genetic factors. Disruption of this can result in microphthalmia, anophthalmia and coloboma (MAC), which is a spectrum of congenital ocular disease with lifelong consequences affecting sight. In...
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Docosahexaenoic Acid Induced Apoptosis In H9c2 Cells And Changed Cardiac Function After Ischemia-Reperfusion Injury
DownloadSpring 2013
Cardiovascular disease (CVD) remains one of the leading causes of death worldwide. As such, a vast amount of research has investigated novel therapies for preventing and/or reducing CVD. Much evidence has demonstrated the importance of dietary composition in increasing or lowering risks of CVD....
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Fall 2011
Taxanes are used for the treatment of breast, ovarian, and lung cancer. Unfortunately, taxane based therapy—the current treatment for metastatic breast cancer—has substantial shortcomings including myelosupression, neurotoxicity, and frequently acquired resistance. Our present understanding of...
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Spring 2014
Anthropogenic contaminants can impair olfactory responses to natural odorants. In fishes, these impairments may be used as a metric of sub-lethal toxicity. My studies aimed to determine the effects of two contaminant sources on fish olfaction as measured by electro-olfactography (EOG). The...
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Regulation of Pancreatic β-cell Life and Death in the Context of Type 2 Diabetes: Study of the Potential Implication of the Orphan Nuclear Receptor NR4A3/Nor1 and the NZF Transcription Factor ST18.
DownloadFall 2017
Background: The insulin-secreting pancreatic beta-cell plays a central role in the maintenance of glucose homeostasis and in the pathogenesis of both type 1 and type 2 diabetes mellitus. In both cases, production of pro-inflammatory cytokines causes beta-cell apoptosis, which results in the...