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Spring 2022

Brown, Douglas Wilson

Gene therapy has potential to become the Holy Grail of modern medicine, however, its clinical success has been hindered due to the lack of a safe and effective nucleic acid delivery platform. The recent success of non-viral RNA delivery platforms has revitalized the field and spurred great...

Fall 2021

Mahshad Moshari

Cancer is a leading cause of death that imposes significant economic and social suffering on a global scale. Based on the projected growth and ageing of populations, the global burden of cancer is set to increase. Despite the vast investment in cancer research, the rate of translation of research...

Spring 2021

Zervopoulos, Sotirios

Pyruvate dehydrogenase complex (PDC) is a mitochondrial enzyme that links glycolysis to oxidative phosphorylation by decarboxylating glucose-derived pyruvate to produce acetyl-CoA that is used in the Krebs cycle. PDC was initially thought to reside only in the mitochondrial matrix but we recently...

Fall 2022

Ford, Katherine L

Patients with cancer are nutritionally vulnerable and at risk of low muscle mass (MM), a primary nutrition problem that independently predicts poor prognosis. Targeted nutrition interventions to optimize muscle health should focus on adequate energy and protein. Many patients alter their diet but...

Fall 2024

Saini, Arashdeep S

In response to hypoxic conditions, tumours secrete pro-angiogenic factors that stimulate the development of new blood vessels. Given the critical role of angiogenesis in tumour progression, therapies counteracting cancer neovascularization have been developed. However, clinical studies have shown...

Spring 2021

Diaz Dussan, Diana M.

Advances in polymer science and nanotechnology have allowed the development of biomaterials for cell-based applications, such as the delivery of a variety of drugs and genes, as well as supporting technologies, such as stem cell therapies, tissue engineering and cryopreservation. The progress in...

Spring 2018

Kinnaird, Adam

Renal cell carcinoma comprises approximately 2-3% of all malignancies, with the majority, approximately 70%, being clear cell renal cell carcinoma (ccRCC). ccRCC features many cancer hallmarks such as suppressed mitochondrial glucose oxidation, apoptosis-resistance, angiogenesis, immune evasion,...

Fall 2021

Purdy, Graeme Macdonald

Introduction: Exercise could help alleviate the significant morbidity experienced by people with multiple myeloma (MM). It is unclear if current cancer-specific exercise guidelines are appropriate for this unique population. Supervision, tailoring, and flexibility are proposed as key program...

Fall 2023

Yukuyama, Megumi N

Nanoemulsions have wide application, presenting several properties such as the solubilization of poorly soluble drugs in water, promoting the increase of their bioavailability, allowing greater stability of the formulation and, due to its property as a carrier, promoting their modified release....

Fall 2014

Zepeda, Nubia I

Chemoresistance is one of the major hurdles to induce a cure in patients with epithelial ovarian cancer (EOC). RUNX3, belonging to the family of RUNX transcription factors, has been shown to act in an oncogenic manner by promoting proliferation and colony formation when overexpressed, in EOC....