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Skip to Search Results- 1Balutis, Andrea M
- 1Bartusiak, Robert
- 1Bentley, Pamela AP
- 1Bhatt, Bhumi J
- 1Blanes, Milena S
- 1Foroutannaddafi, Aidin
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Molecular and Machine Learning Based Characterization of Human Skeletal Muscle to Decipher Complex Biological Processes Governing Muscle Wasting in Surgical Patients with Cancer
DownloadSpring 2023
Cancer cachexia is a multifactorial syndrome characterized by progressive loss of weight (WL), muscle, and fat tissues. Skeletal muscle wasting, in particular, is strongly associated with morbidity and mortality. Understanding the pathophysiological mechanisms underlying muscle wasting in humans...
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Spring 2018
Identification of bacterial isolates is important for taxonomic purposes, as well as to predict behaviour and properties of organisms in evolutionary, ecological, industrial, or medical contexts. This process embraces a polyphasic approach (phenotypic, genotypic, and phylogenetic), but has been...
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The effects of intermittent suckling protocols on reproductive performance in primiparous sows
DownloadFall 2017
In pig production, sow reproductive efficiency is a key contributor to breeding herd productivity. A major challenge in the implementation of alternative sow housing and piglet management systems is the maintenance of production efficiency. Conventionally, sows are only bred once they come into...
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How studying the interaction of Sir4 with a subset of Nups uncovered a new chromatin bound complex.
DownloadFall 2017
The nucleus is the defining feature of eukaryotic cells and its major function is to house the cell’s genome and segregate it from the surrounding cytoplasm. The membranes encapsulating the nucleus constitute the nuclear envelope (NE). The interactions between the NE and chromatin facilitate the...
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Profiling and Identification of Post-Transcriptional Regulatory Molecules for Human Cancer Cachexia
DownloadSpring 2017
Cancer cachexia (CC) is a multifactorial syndrome characterized by severe depletion of skeletal muscle, with or without fat loss. A majority of cancer patients with incurable cancer are affected with cachexia and it remains an unmet medical need. Gene expression changes at the transcriptional...
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Spring 2017
Survival prediction is becoming a crucial part of treatment planning for most terminally ill patients. Many believe that genomic data will enable us to better estimate survival of these patients, which will lead to better, more personalized treatment options and patient care. As standard...
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STRESS RESPONSES OF THE FLAX GENOME: ACTIVATION OF TRANSPOSABLE ELEMENTS, DEFENSE GENES AND GENOME RESTRUCTURING AND DIVERSIFICATION.
DownloadSpring 2017
Transposable elements (TEs) are DNA sequences that can move in the genome (transpose) via a DNA or a RNA intermediate. TEs are abundant in plant genomes and can be activated by stress. Their activity can result in structural and gene expression alterations that increase diversity within and among...
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The biology and characterization of NOD-like receptors in goldfish (Carassius auratus L.) macrophages exposed to bacterial pathogens
DownloadSpring 2017
The recognition of pathogen-associated molecular patterns (PAMPs) by pattern recognition receptors (PRRs) is important for the initiation of the host defense against pathogens. NOD-like receptors (NLRs) are a family of PRRs that primarily detect the cytosolic PAMPs of the pathogens. The NLRs have...
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Gene expression and sensory structures in sponges: Explorations of sensory-neural origins in a non-bilaterian context
DownloadFall 2017
The nervous system is present in all but two animal phyla – one of them being Porifera, sponges. Sponges have no neurons and yet have organized behavior and finely tuned sensation. Furthermore, sponges have genes involved in the nervous system of other animals (informally called ‘neural’ genes)....
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Application of Next Generation Sequencing and Bioinformatic Approaches to the Study of Influenza Virus Strains and MiRNA Profiling in Liver Diseases
DownloadSpring 2016
Analysis and interpretation of next generation sequencing data has posed a significant challenge to researchers, especially to those who are not equipped with expertise in bioinformatics. In this thesis, I investigated three different biomedical questions using NGS and bioinformatic approaches,...