Search
Skip to Search Results- 7Graduate and Postdoctoral Studies (GPS), Faculty of
- 7Graduate and Postdoctoral Studies (GPS), Faculty of/Theses and Dissertations
- 2Roy Berg Kinsella Research Ranch
- 2Roy Berg Kinsella Research Ranch/Journal Articles (Kinsella Ranch)
- 1Agricultural, Food and Nutritional Science, Department of
- 1Agricultural, Food and Nutritional Science, Department of/Journal Articles (Agricultural, Food and Nutritional Science)
- 2Baracos, Vickie (Oncology)
- 2Putman, Charles (Physical Education and Recreation)
- 1Ali, Declan W. (Biological Sciences)
- 1Baracos, Vickie (Oncology & Agricultural, Food, and Nutritional Science)
- 1Damaraju, Sambasivarao (Laboratory Medicine and Pathology)
- 1Mazurak, Vera (Agricultural, Food and Nutritional Science)
-
Elevated Fatty Acid Content in Muscle is Prevented by EPA and DHA in an Animal Model of Colorectal Cancer Receiving CPT-11 / 5-FU
DownloadFall 2012
This study aimed to assess the effect of irinotecan / 5-fluorouracil treatment on amount and types of fatty acids in skeletal muscles of tumor-bearing rats fed: a) control diet, b) fish oil diet. Rats bearing the Ward colorectal carcinoma were fed a semi-purified diet with or without fish oil...
-
Fibre-Type Specific Nuclear Localisation Patterns of NFAT-isoforms in CLFS Induced Skeletal Muscle Adaptations
DownloadSpring 2014
The purpose of this investigation was to characterize the nuclear localisation patterns of NFAT-c1, -c2, -c3, and -c4 in relation to chronic low-frequency stimulation induced fibre type transitions. A model has been suggested to describe the roles of all 4 NFAT isoforms in activity-dependent...
-
Maternal and Paternal Genomes Differentially Affect Myofibre Characteristics and Muscle Weights of Bovine Fetuses at Midgestation
Download2013
Kruk, Z. A., Xiang R., Rutley, D. L., Thomsen, D. A., Anderson, G. I., Fitzsimmons, C., Ghanipoor-Samami, M., Hiendleder, S., Roberts, C. T., Eindorf, T., Burns, B. M., Greenwood, P. L., Johns, W. H.
Postnatal myofibre characteristics and muscle mass are largely determined during fetal development and may be significantly affected by epigenetic parent-of-origin effects. However, data on such effects in prenatal muscle development that could help understand unexplained variation in postnatal...
-
MicroRNA Buffering and Altered Variance of Gene Expression in Response to Salmonella Infection
Download2014
Plastow, G. S., Bao, H., Kommadath, A., Guan, L. L., Tuggle, C. K., Stothard, P.
One potential role of miRNAs is to buffer variation in gene expression, although conflicting results have been reported. To investigate the buffering role of miRNAs in response to Salmonella infection in pigs, we sequenced miRNA and mRNA in whole blood from 15 pig samples before and after...
-
Profiling and Identification of Post-Transcriptional Regulatory Molecules for Human Cancer Cachexia
DownloadSpring 2017
Cancer cachexia (CC) is a multifactorial syndrome characterized by severe depletion of skeletal muscle, with or without fat loss. A majority of cancer patients with incurable cancer are affected with cachexia and it remains an unmet medical need. Gene expression changes at the transcriptional...
-
Fall 2009
Skeletal muscle is a heterogeneous, multinucleated, post-mitotic tissue that contains many functionally diverse fibre types that are capable of adjusting their phenotypic properties in response to altered contractile demands. This plasticity, or adaptability of skeletal muscle is largely...
-
Skeletal muscle anabolism is a side effect of therapy with the MEK inhibitor: Selumetinib in patients with cholangiocarcinoma
Download2012
Ghosh, Sunita, Doyle, L. Austin, Baracos, Vickie E., Prado, Carla M., Sawyer, Michael B., Bekaii-Saab, Tanios, Shrestha, Suraj
background: Cancer cachexia is characterised by skeletal muscle wasting; however, potential for muscle anabolism in patients with advanced cancer is unproven. methods: Quantitative analysis of computed tomography images for loss/gain of muscle in cholangiocarcinoma patients receiving selumetinib...
-
Fall 2014
The purpose of this work is to understand properties of skeletal muscle of cancer patients experiencing severe muscle depletion. These studies were done using computed tomography (CT) imaging and patient information (demographics), and collection of muscle biopsies to analyze using flow...
-
Fall 2013
Cancer cachexia is a multifactorial syndrome characterized by involuntary weight loss, wasting of skeletal muscle driven by reduced food intake and abnormal metabolism. Cachexia has a negative impact on quality of life, response to chemotherapy and survival. Cachexia research is undeveloped with...
-
Zebrafish embryos exposed to alcohol undergo abnormal development of motor neurons and muscle fibers
DownloadFall 2009
Children with Fetal Alcohol Spectrum Disorder have significantly delayed motor skills, and deficiencies in reflex development. The reasons underlying these motor deficits are not fully understood. The purpose of this thesis was to investigate the effect of embryonic exposure to ethanol (EtOH) on...