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Skip to Search Results- 22Metabolomics
- 8Mass-spectrometry
- 6Chemical isotope labeling
- 5LC-MS
- 3Dansylation
- 3Metabolite identification
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Method Development of Chemical Isotope Labeling of Cellular Extract and Biofluids on Metabolomics Profiling and Its Application for Disease Biomarker Discovery
DownloadFall 2019
Metabolomics aims at studying all the small molecules in biological samples. Compared to transcriptome and proteome, metabolome is highly sensitive to diverse individuals and environmental factors. Thus, metabolomics study has been used to understand individual variations caused by genes,...
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Spring 2022
Metabolomics, as an interdisciplinary research area, requires the integration of knowledge from different disciplines, such as analytical chemistry, bioinformatics, and statistics. The general workflow of metabolome analysis includes sample preparation, data acquisition, data processing, data...
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Metabolomics by GC×GC-TOFMS: Overcoming Challenges from Sample Preparation to Data Analysis Towards Standardization of the Workflow
DownloadSpring 2021
Metabolomics is an ‘omics’ field, which involves the comprehensive characterization of metabolites using analytical chemistry technologies and statistical methods to interpret the results. The term metabolomics was coined about two decades ago as an analogy to other precedent omics approaches:...
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Metabolite Identification and Quantification in Biofluids Using Liquid Chromatography Mass Spectrometry
DownloadFall 2012
Metabolomics, one of the branches of systems biology, is the comprehensive measurement of all the endogenous metabolites in a biological system. It can be applied in the areas of biomarker discovery and diagnosis of critical diseases and disorders, and can significantly increase our understanding...
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Isotope Labeling Liquid Chromatography Mass Spectrometry: Metabolite Identification and Human Salivary Metabolome Profiling
DownloadFall 2012
The objective of this work was to use paired labeling reagents that are chemically identical but isotopically different to provide a simple and robust way of mass spectrometry (MS)-based metabolome profiling. A differential 13C-/12C-isotope dansyl chloride (DnsCl) derivatization strategy has been...
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Evaluation of Derivatization Reaction Conditions for Metabolite Labelling Using Differential Isotopic Labelling for Biological Samples Analyzed by Liquid Chromatography Mass Spectrometry
DownloadFall 2013
The objective of this work was to assess the impact of reaction conditions for isotopic labeling of metabolites prior to analysis using liquid chromatography mass spectrometry (LC-MS). Differential isotope 12C/13C dansyl chloride was used to label metabolites containing either primary amines,...
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Differential 15N2-/14N2-isotope Dansylhydrazine Labeling and LC-MS for Quantification of the Human Carbonyl Metabolome
DownloadFall 2011
The objective of this work was the design and use of paired labeling reagents that are chemically identical but isotopically different to provide a simple and robust means of quantitative mass spectrometry (MS) based metabolome profiling. Herein is presented the differential 15N2-/14N2-isotope...
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Fall 2017
The most often used biofluids in metabolomics and disease biomarker discovery studies in the literature include urine, processed blood (serum or plasma), and cerebral spinal fluid. While investigations using these biofluids have led to numerous innovations in the field of metabolomics, little...
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Development of Liquid Chromatography Mass Spectrometry Methods for the Identification and Quantification of Acylcarnitines in Biological Samples
DownloadFall 2012
The field of metabolomics follows the Greek premise where metabolic changes are believed to be indicative of disease. Acylcarnitines, for example, can be dysregulated in the presence of various diseases including genetic metabolic disorders and multiple sclerosis. Liquid chromatography mass...
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Spring 2016
The analysis of thousands of metabolites and lipids for discovery of metabolite biomarkers for disease monitoring and diagnosis requires the highest sensitivity and robust methods. Metabolomics is the study of metabolites found in the body, which can be used to discover biomarkers of disease or...