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Fall 2019
Background: Dermal fibroproliferative disorders are forms of aberrant cutaneous wound healing, which can lead to the formation of hypertrophic scars (HTS). HTS develop after prolonged healing of deep dermal burns and are associated with excessive inflammation. HTS are characterized by exaggerated...
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Investigation of the functional role of endothelial KCa channels in regulation of resistance artery diameter
DownloadSpring 2018
Background: The vascular endothelium regulates arterial diameter, and thus blood flow and pressure, through release of diffusible factors such as nitric oxide (NO), and spread of electrical charge to smooth muscle cells via myoendothelial gap junctions (MEGJs). Activation of these pathways is...
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The relationship between nitric oxide synthase expression and nitric oxide mediated inhibition of vasoconstriction
DownloadSpring 2018
Nitric oxide (NO) is a ubiquitous signal molecule with many biological functions. NO is produced through the reaction of L-arginine with O2, which is catalyzed by the family NO synthase (NOS) enzymes. NOS exists in endothelial (eNOS), neuronal (nNOS) and inducible (iNOS) isoforms and the eNOS...
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Fall 2018
Mast cells (MCs) are tissue resident innate immune cells. They are recognized for their immunoregulatory roles in the regulation of innate and adaptive immunity. Aberrant activation and responses of MCs result in inflammatory disorders like allergies. Thus, the biological pathways that control MC...
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Spring 2016
Schizophrenia is a complex neurodevelopmental illness that often requires a combination of treatments to adequately control its symptoms. Despite the availability of several neuroleptic medications on the market, many patients with schizophrenia remain symptomatic. Research has shifted...
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Spring 2016
Preeclampsia, defined as new-onset hypertension after 20 weeks of gestation with concurrent proteinuria, is the leading cause of maternal mortality. Preeclampsia is a multi-system disorder with serious maternal and fetal morbidities, which affects 2 – 8% of pregnancies worldwide. Although the...
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Fall 2016
Introduction: Hypertrophic scar (HTS) formation is a fibroproliferative disorder that commonly follows deep dermal burns with prolonged inflammation. It is characterized by excessive extracellular matrix such as collagen deposition mainly by dermal fibroblasts. Mast cells have been implicated in...
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Spring 2011
Nitric oxide (NO) is a short-lived free radical that plays a critical role in the regulation of cellular signalling. Mast cell (MC) derived NO and exogenous NO regulate MC activities including the inhibition of MC degranulation. At a molecular level the intermediate metabolites of NO modify...
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Expression and functional significance of the cystic fibrosis transmembrane conductance regulator (CFTR) in human mast cells
DownloadFall 2009
Mast cells (MC) are present in nearly all tissues in the body and participate in many physiological processes including allergy, tissue remodelling, fibrosis, angiogenesis, and autoimmunity. They can be activated by many stimuli, including allergic and innate immune stimulation. When activated,...
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Fall 2009
Skeletal muscle is a heterogeneous, multinucleated, post-mitotic tissue that contains many functionally diverse fibre types that are capable of adjusting their phenotypic properties in response to altered contractile demands. This plasticity, or adaptability of skeletal muscle is largely...