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Skip to Search Results- 2Veldhoen, Richard
- 1Alsaleh, Nasser B
- 1Githaka, John M
- 1Harbison, Adrian Mark.
- 1Herrera, Maria S
- 1Howlader, Md Amran
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Fall 2017
Protein prenylation is the post-translational addition of isoprenoid lipid moieties to proteins, which regulates their subcellular localization and function. Farnesyl or geranylgeranyl isoprenoids are covalently linked to cysteines residues in a C-terminal prenylation recognition sequence in...
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Spring 2016
Background: Huntington’s disease (HD) is an inherited neurodegenerative disorder caused by an expanded polyglutamine tract in the huntingtin (HTT) protein. Mutant huntingtin (mHTT) accumulates as toxic oligomers and aggregates inside the cell, when it is not removed efficiently by selective...
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Plasma Membrane Organization and Endocytosis of CD36 in Human Microvascular Endothelial Cells
DownloadSpring 2016
The plasma membrane is a dynamic lipid bilayer that surrounds the cell, embedded with different plasma membrane proteins, aiding communication between the inside and outside of the cells. Its functions are achieved through an intricate organization of lipid-lipid, lipid-protein and...
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Fall 2011
Taxanes are used for the treatment of breast, ovarian, and lung cancer. Unfortunately, taxane based therapy—the current treatment for metastatic breast cancer—has substantial shortcomings including myelosupression, neurotoxicity, and frequently acquired resistance. Our present understanding of...
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Fall 2011
Taxanes are used for the treatment of breast, ovarian, and lung cancer. Unfortunately, taxane based therapy—the current treatment for metastatic breast cancer—has substantial shortcomings including myelosupression, neurotoxicity, and frequently acquired resistance. Our present understanding of...
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Spring 2014
Epoxyeicosatrienoic acids (EET) are cytochrome P450 epoxygenase metabolites of arachidonic acid. Evidence shows that they mediate protective effects in the cardiovascular system promoting cell survival. In this thesis, the major focus was to investigate if and how EETs regulate autophagy in...
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Spring 2020
The human neuraminidases (NEU1, NEU2, NEU3, and NEU4) are a family of enzymes implicated in pathologies including cancer and diabetes. Our group has developed selective inhibitors for these enzymes that have been employed as tools to understand their biological roles. Several reports have linked...
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Mammalian and Saccharomyces cerevisiae ER-mitochondria contact site regulation by small Rab GTPases and ER folding assistants
DownloadFall 2021
Membrane-bound organelles allow eukaryotes to compartmentalize components and processes in a highly organized manner. Organelles can communicate with one another through membrane contact sites (MCS): membrane appositions 10-50nm apart. MCS were not widely accepted as bona fide sites of organelle...
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Magazine Images Depicting the Ideal Fit Male Body: An Outlet for Influencing Body Perceptions and Exercise Related Cognitions
DownloadFall 2012
This study examined the effects of viewing health/fitness and sports magazine images on body perceptions and exercise related cognitions in males. The moderating effects of age were also examined. A series of 3 (image-only, magazine cover, control) by 3 (youngest, middle, oldest) ANOVA analyses...
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Fall 2018
Huntington’s disease (HD) is a monogenic neurodegenerative disorder characterized by progressive choreic movements, dystonia, motor incoordination, cognitive decline and behavioural changes. HD is caused by an abnormal increase in the number of CAG repeats in the exon 1 of the huntingtin (HTT)...