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Skip to Search Results- 6Klassen, John S.
- 4Kitova, Elena N.
- 2Bagal, Dhanashri
- 2Basu, U.
- 2Campuzano, Iain D. G.
- 2Daneshfar, Rambod
- 29Graduate and Postdoctoral Studies (GPS), Faculty of
- 29Graduate and Postdoctoral Studies (GPS), Faculty of/Theses and Dissertations
- 13Biological Sciences, Department of
- 13Biological Sciences, Department of/Journal Articles (Biological Sciences)
- 7Chemistry, Department of
- 7Chemistry, Department of/Journal Articles (Chemistry)
- 5Department of Chemistry
- 5Department of Electrical and Computer Engineering
- 3Department of Agricultural, Food, and Nutritional Science
- 3Department of Mechanical Engineering
- 2Department of Biological Sciences
- 2Department of Physics
- 2Bhattacharjee, Subir (Mechanical Engineering)
- 2Kurgan, Lukasz (Electrical and Computer Engineering)
- 1Ball, Ronald O. (Department of Agricultural, Food and Nutritional Science)
- 1Ballermann, Barbara (Medicine)
- 1Bergren, Adam (National Institute for Nanotechnology)
- 1Boekhoven, Job (Chemistry, Technical University of Munich)
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Fall 2016
α-Synuclein has been implicated in the progression of Parkinson’s disease, a neurodegenerative disorder that affects millions of people worldwide. This work reports on the structural propensity and druggability of this protein using a combination of Monte Carlo, Molecular Dynamics, and Virtual...
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Computational support systems for prediction and characterization of protein crystallization outcomes
DownloadFall 2013
Analysis of protein structures may reveal their function, regulation and interactions. Almost 90% of the known protein structures were solved using X-ray crystallography; however, many more structures remain unsolved. Protein Structure Initiative (PSI) project was created to speed up structure...
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2012
Law, G. K., Forbes, J. F., Elliott, J. A., McGann, L. E., Jomha, N. M., Prasad, V., Almansoori, K. A.
Background Vitrification is a method of cryopreservation by which cells and tissues can be preserved at low temperatures using cryoprotective agents (CPAs) at high concentrations (typically ⩾6.0 M) to limit the harmful effects of ice crystals that can form during cooling processes. However, at...
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Crystallization and preliminary diffraction studies of TraF, a component of the Escherichia coli type IV secretory system
Download2004
Manchak, J., Hayakawa, K., Audette, G.F., Holland, S.J., Frost, L.S., Hazes, B.
TraF, a component of the Escherichia coli type IV secretory system, has been crystallized and preliminary X-ray diffraction data have been collected. TraF is a 26 kDa protein encoded by the E. coli F plasmid and is required for conjugative plasmid transfer and the formation of sex pili. The...
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2014-10-27
Wu, Xiaolei , Wafula, Eric , Yan, Zhixiang , Kutchan, Toni M. , Gitzendanner, Matthew A, Shaw, Jonathan A., Chen, Tao. , Wickett, Norman J., Nguyen, Nam , Burleigh, J Gordon , Miles, Nicholas W. , Soltis, Pamela S. , Melkonian, Michael , Deyholos, Michael K. , Matasci, Naim , DeGironimo, Lisa , Samudrala, Ram , Leebens-Mack, Jim , Mirarab, Siavash , Barker, Michael , Sun, Xiao , Soltis, Douglas E. , Rolf, Megan , Tian, Zhijian , Wong, Gane K, Rothfels, Carl , Pokorny, Lisa , Zhang, Yong , Ayyampalayam, Saravanaraj , Graham, Sean W. , Roure, Béatrice, Der, Joshua P., Wang, Jun , Mathews, Sarah , Surek, Barbara , Baucom, Regina S. , Ruhfel, Brad R. , Villarreal, Juan C., Stevenson, Dennis W. , Hung, Ling-Hong , Warnow, Tandy , Philippe, Hervé , Carpenter, Eric J.
The 1,000 plants (1KP) project is an international multi-disciplinary consortium that has generated transcriptome data from over 1,000 plant species, with exemplars for all of the major lineages across the Viridiplantae (green plants) clade. Here, we describe how to access the data used in a...
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Design and performance evaluation of vertical shafts: rational shaft design method and verification of design method
Download1988
Ground deformations around axisymmetric shafts cannot be determined with the design approaches currently available, which are mostly based on plasticity methods. The convergence–confinement method (usually applied to tunnels), with consideration of gravitational effects and the three-dimensional...
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2016
Klassen, John S., Han, Ling, Kitova, Elena N.
This study reports on the use of the catch-and-release electrospray ionization mass spectrometry (CaR-ESI-MS) assay, combined with glycomicelles, as a method for detecting specific interactions between water-soluble proteins and glycolipids (GLs) in aqueous solution. The B subunit homopentamers...
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2016
Han, Ling, Klassen, John S., Kitova, Elena N.
This study reports on the use of the catch-and-release electrospray ionization mass spectrometry (CaR-ESI-MS) assay, combined with glycomicelles, as a method for detecting specific interactions between water-soluble proteins and glycolipids (GLs) in aqueous solution. The B subunit homopentamers...
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Development and Analysis of Magnetic Carbon Nanotube and Microbubble-Assisted High Centrifugation Field Techniques For The Increase of Cell Membrane Permeability
DownloadSpring 2014
To cure diseases at the gene level, therapeutic biomaterials need to enter the cells. However, since the cell membrane is a highly selective structure, its permeability is usually very low. In this thesis, we propose two innovative and efficient methods to increase cell membrane permeability....
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Development and Application of Protected Amino Acids for the Installation of Stable Post-translational Modifications Using Solid-Phase Peptide Synthesis
DownloadFall 2022
This thesis describes the synthesis of non-canonical amino acid building blocks and their use in solid-phase peptide synthesis (SPPS) to explore peptidic drug analogues based on natural products. We replaced sensitive functionalities found in the structure of naturally produced peptides with...