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Skip to Search Results- 1Adam, Ibrahim S. Y.
- 1Casey, Geoffrey A
- 1Chou, Ying
- 1Coulombe, Marilyne G.
- 1Gavina, Kenneth C
- 1Goldansaz, Seyed Ali
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Toxic effects induced in mammalian immune cells after in vitro exposure to oil sands process-affected water and its fractions
DownloadFall 2019
Oil sands process-affected water (OSPW) is produced by the surface mining industry in Alberta as a byproduct of the Clark hot water process, the currently used extraction method of crude oil from bitumen/tar sands. Under a provincial zero release policy all produced OSPW must be stored on site....
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Fall 2017
The inflammatory response is a complex biological process initiated following the recognition of noxious stimuli. It is composed of an elaborate cascade of both pro- and anti-inflammatory mediators, essential for effective defenses against infection, the removal of damaged cells, and the...
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The Role of Haemocytes in the Immune Response of Biomphalaria glabrata against Schistosoma mansoni: Investigations into Haematopoiesis and Pattern Recognition Receptors
DownloadSpring 2018
Snails (Gastropoda) serve as hosts for the larval development of many medically and agriculturally important digenean trematodes (parasitic flatworms), including schistosomes, blood flukes that collectively infect more than 260 million people globally. Compatibility between snails and digeneans...
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Phage Display Derived Fragment-based Discovery of Antigens for Antibodies associated with Mycobacterial Infections
DownloadSpring 2017
Tuberculosis (TB) remains a global health problem. Incorrect or missed serodiagnosis for TB, especially in resource-limited settings, is one of the main reasons for TB epidemics. Clinically, serological tests that use circulating antibodies are attractive because antibodies in serum are present...
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Investigation of the Molecular Mechanisms That Determine Isolate-Specific, Antibody-Mediated Neutralization of HCV infectivity
DownloadFall 2018
It is estimated that there are about 1.75 million new Hepatitis C Virus (HCV) infections per year worldwide and around 20% will develop liver cirrhosis or liver cancer if left untreated. Direct acting antiviral drugs are available for the treatment of HCV with success rates of over 90%. But...
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Innate Immunity and the Retinal Pigment Epithelium in Gene Therapy for Inherited Retinal Disorders
DownloadFall 2021
Background: The photoreceptors are post-mitotic (no longer dividing), so the eye has evolved several unique immunological mechanisms to protect the photoreceptors and prevent vision loss. Inherited retinal disorders occur when mutations disrupt normal retinal function and photoreceptors die....
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Evaluating the Role of Bacterial Lipopolysaccharide on Etiology and Pathogenesis of Transmissible Spongiform Encephalopathies
DownloadFall 2014
Transmissible spongiform encephalopathies (TSEs) or otherwise known as prion diseases are a class of fatal neurodegenerative diseases related to irreversible brain damage. Presently, there is no effective treatment or preventive strategy for this disease because the etiology and biological...
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Clinical impact of submicroscopic malaria on delivery outcomes and the role of VAR2CSA antibodies in pregnant women from Colombia
DownloadFall 2018
Malaria caused by the genus Plasmodium (P.) is one of the oldest and most important parasitic infections globally. Pregnant women are at an increased risk for malaria, where the disease poses a significant risk to both maternal and child health. Better diagnosis of malaria can have an immediate...
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Fall 2012
Teleosts rely on innate immunity to protect themselves from pathogens. Colony stimulating factor-1 (CSF-1) and its cognate receptor CSF-1R control survival, proliferation, differentiation and function of macrophages. Recently, a novel soluble form of CSF-1R (sCSF-1R) was identified in goldfish....