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Skip to Search Results- 3Chakrabarti, Subhadeep
- 3Proctor, Spencer D.
- 3Wu, Jianping
- 2Aguzzi, Adriano
- 2AlZahal, Ousama
- 2Ametaj, Burim N.
- 42Graduate and Postdoctoral Studies (GPS), Faculty of
- 42Graduate and Postdoctoral Studies (GPS), Faculty of/Theses and Dissertations
- 20Agricultural, Food and Nutritional Science, Department of
- 20Agricultural, Food and Nutritional Science, Department of/Journal Articles (Agricultural, Food and Nutritional Science)
- 2Pharmacy and Pharmaceutical Sciences, Faculty of
- 2Roy Berg Kinsella Research Ranch
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Fall 2014
Epidemiological studies correlate vitamin D deficiency with asthma severity. Calcitriol modulates receptor and cytokine expression from various leukocytes in an anti-inflammatory manner. Despite eosinophil activity during mucosal inflammation, knowledge on the direct effect of calcitriol on this...
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Vaccenic and elaidic acid modify plasma and splenocyte membrane phospholipids and mitogen-stimulated cytokine production in obese insulin resistant JCR:LA-cp rats
Download2010
Ruth, Megan R., Reaney, Martin J., Vine, Donna F., Goruk, Susan, Yu, Howe-Ming, Field, Catherine J., Proctor, Spencer D., Wang, Ye
This study assessed the long-term effects of dietary vaccenic acid (VA) and elaidic acid (EA) on plasma and splenocyte phospholipid (PL) composition and related changes in inflammation and splenocyte phenotypes and cytokine responses in obese/insulin resistant JCR:LA-cp rats. Relative to lean...
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Understanding postprandial inflammation and its relationship to lifestyle behaviour and metabolic diseases
Download2012
Cabezas, Manuel C., Mamo, John C., Proctor, Spencer D., Botham, Kathleen M., Klop, Boudewijn
Postprandial hyperlipidemia with accumulation of remnant lipoproteins is a common metabolic disturbance associated with atherosclerosis and vascular dysfunction, particularly during chronic disease states such as obesity, the metabolic syndrome and, diabetes. Remnant lipoproteins become attached...
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Transcriptomic and epigenetic profiling of the lung of influenza-infected pigs: A comparison of different birth weight and Susceptibility groups
Download2015-09-22
Harding, John C.S., Foxcroft, George R., Gunvaldsen, Rayna E., Dyck, Michael K., Plastow, Graham S., Detmer, Susan E., Wilkinson, Jamie M., Dixon, Walter T.
Influenza viruses are a common cause of respiratory disease in swine. Infections range in severity from asymptomatic to causing significant morbidity. The main objective of this study was to compare lung transcriptomic and epigenetic responses to influenza infection in pigs from high or low birth...
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Spring 2015
The tumor suppressor protein Ras association domain family 1A (RASSF1A) has roles in multiple signaling pathways including modulating apoptosis, the cell cycle, DNA damage, and microtubule organization. RASSF1A has been shown to be one of the most frequently epigenetically silenced genes in a...
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Fall 2017
The inflammatory response is a complex biological process initiated following the recognition of noxious stimuli. It is composed of an elaborate cascade of both pro- and anti-inflammatory mediators, essential for effective defenses against infection, the removal of damaged cells, and the...
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Spring 2017
MS is a chronic demyelinating disease of the CNS that presents with debilitating symptoms in the later stages of disease progression and therefore a high demand for targeted disease-modifying treatments exists. In order to create effective treatments the causalities between the symptoms and...
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The prognosis and outcomes of patients with a ST-segment elevation myocardial infarction and the biochemical and clinical inflammatory response
DownloadSpring 2013
Acute myocardial infarction, and specifically coronary plaque rupture, has been associated with a systemic inflammatory cascade. Using multiple large clinical trial datasets, we sought to further understand the systemic and clinical inflammatory responses in patients with ST-elevation myocardial...
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The POM monoclonals: A comprehensive set of antibodies to non-overlapping prion protein epitopes
Download2008
Hafner-Bratkovič, Iva, Aguzzi, Adriano, Vey, Martin, Polymenidou, Magdalini, Yajima, Bill , James, Michael N. G., Jerala, Roman, Moos, Rita, Scott, Mike, Shi, Yong-zhong, Wuthrich, Kurt, Garen, Graciela, Sigurdson, Christina, Hornemann, Simone, Bellon, Anne, Kav, Nat
PrPSc, a misfolded and aggregated form of the cellular prion protein PrPC, is the only defined constituent of the transmissible agent causing prion diseases. Expression of PrPC in the host organism is necessary for prion replication and for prion neurotoxicity. Understanding prion diseases...