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- 3Wu, Jianping
- 2Chakrabarti, Subhadeep
- 2Davidge, Sandra T.
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- 16Graduate and Postdoctoral Studies (GPS), Faculty of
- 16Graduate and Postdoctoral Studies (GPS), Faculty of/Theses and Dissertations
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- 3Agricultural, Food and Nutritional Science, Department of/Journal Articles (Agricultural, Food and Nutritional Science)
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- 2Fernandez-Patron, Carlos (Biochemistry)
- 1Al Hamarneh, Yazid (Pharmacology)
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- 1Carlos A Velázquez (Faculty of Pharmacy and Pharmaceutical Sciences)
- 1Davidge, Sandra (dept. of Physiology)
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Hemodynamic Changes in the Prefrontal Cortex during Functional Activation in Essential Hypertension Measured by Near Infrared Spectroscopy
DownloadFall 2014
Chronic hypertension induces microvascular changes in the prefrontal cortex (PFC) which could influence oxygenation status. However, hypertension-related changes in oxygenation in the PFC and cognition, especially during functional stresses, remain poorly investigated. This project consisted of...
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Spring 2011
Angiotensin II signals cardiovascular disease through metalloproteinases including MMP-2, MMP-7 and ADAM-17/TACE. We hypothesized that these metalloproteinases regulate each other at the transcriptional level. Further, MMP-2, being a major gelatinase in cardiac and vascular tissue, could mediate...
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Fall 2013
Despite many decades of research and drug development, the diseases of the cardiovascular system remain a major health threat in the modern world. Hypertensive cardiac disease is a cardiovascular condition characterized by the co-occurrence of hypertension and pathological cardiac remodeling...
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Molecular targets of antihypertensive peptides: Understanding the mechanisms of action based on the pathophysiology of hypertension
Download2015
Majumder, Kaustav, Wu, Jianping
There is growing interest in using functional foods or nutraceuticals for the prevention and treatment of hypertension or high blood pressure. Although numerous preventive and therapeutic pharmacological interventions are available on the market, unfortunately, many patients still suffer from...
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Notch regulates the growth-promoting nitric oxide cGMP-dependent pathway in epithelial ovarian cancer and ovarian surface epithelium cells
DownloadSpring 2014
El-Sehemy, Ahmed Ali Ahmed Ali
Ovarian cancer is the leading cause of mortality among gynecologic cancers. There are several subtypes of ovarian cancer, amongst which epithelial ovarian cancer (EOC) makes up to 90% of all ovarian cancers. The current treatment for EOC consists of debulking surgery followed by a...
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NSAID Prodrugs with Improved Anti-inflammatory Activity and Low Ulcerogenicity: Wake Up Call to Pharmaceutical Companies and Health Authorities
DownloadSpring 2012
The objective of this work was to synthesize and evaluate the biological properties of a new series of nitric oxide-releasing non-steroidal anti-inflammatory drugs (NO-NSAIDs) possessing a tyrosol linker between the carboxylic acid present in classical NSAIDs and a NO-releasing group (PROLI/NO)...
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Pharmacist Management of Hypertension: An Examination of Clinical and Economic Outcomes and Remuneration for Expanded Services
DownloadSpring 2014
Background: One-third of Canadian adults with hypertension remain uncontrolled. As drug therapy experts, pharmacists can play a role in addressing this challenge, particularly when utilizing prescribing authorization in Alberta. However, the clinical effectiveness of pharmacist management of...
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Remodeling of aorta extracellular matrix as a result of transient high oxygen exposure in newborn rats: implication for arterial rigidity and hypertension risk
Download2014-01-01
Huyard, Fanny, Yzydorczyk, Catherine, Castro, Michele M., Cloutier, Anik, Bertagnolli, Mariane, Sartelet, Hervé, Schulz, Richard, Nuyt, Anne Monique
Neonatal high-oxygen exposure leads to elevated blood pressure, microvascular rarefaction, vascular dysfunction and arterial (aorta) rigidity in adult rats. Whether structural changes are present in the matrix of aorta wall is unknown. Considering that elastin synthesis peaks in late fetal life...
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Spring 2021
As one of the most accessible primary health care providers, pharmacists are in an excellent position to provide primary health care services. Although slow, the current transition from a dispensing-centered (transaction-based) pharmacy approach to a patient-centered (patient care based) approach...
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Spring 2016
Introduction: Lumbar Spinal Stenosis (LSS) is a prevalent musculoskeletal condition affecting 8-11% of the United States general population. LSS is the most common reason requiring lumbar spine surgery in adults older than 65 years, with an adjusted rate of 135.5 low back surgeries per 100,000...