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Birth Weight, Intrauterine Growth Retardation and Fetal Susceptibility to Porcine Reproductive and Respiratory Syndrome Virus
Download2014
Ashley, C., Foxcroft, G., Plastow, G., Harding, J. C. S., Lunney, J. K., Ladinig, A.
The severity of porcine reproductive and respiratory syndrome was compared in pregnant gilts originating from high and low birth weight litters. One-hundred and eleven pregnant gilts experimentally infected with porcine reproductive and respiratory syndrome virus on gestation day 85 (±1) were...
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Pathologic Evaluation of Type 2 PorcineReproductive and Respiratory SyndromeVirus Infection at the Maternal-FetalInterface of Late Gestation Pregnant Gilts
Download2016-03-10
Novakovic, Predrag, Harding, John C. S., Al-Dissi, Ahmad, Ladinig, Andrea, Detmer, Susan E.
The pathogenesis of fetal death caused by porcine reproductive and respiratory syndromevirus (PRRSV) remains unclear. The objective of this study was to improve our understand-ing of the pathogenesis by assessing potential relationships between specific histopatho-logical lesions and PRRSV RNA...
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Variation in Fetal Outcome, Viral Load and ORF5 Sequence Mutations in a Large Scale Study of Phenotypic Responses to Late Gestation Exposure to Type 2 Porcine Reproductive and Respiratory Syndrome Virus
Download2014
Plastow, G., Lunney, J. K., Ladinig, A., Ashley, C., Detmer, S. E., Wilkinson, A., Harding, J. C. S.
In spite of extensive research, the mechanisms of reproductive disease associated with Porcine Reproductive and Respiratory Syndrome virus (PRRSv) are still poorly understood. The objectives of this large scale study were to evaluate associations between viral load and fetal preservation,...
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Maternal and fetal predictors of fetal viral load and death in third trimester, type 2 porcine reproductive and respiratory syndrome virus infected pregnant gilts
Download2015-09-25
Wilkinson, Jamie M., Lunney, Joan K., Detmer, Susan E., Ladinig, Andrea, Harding, John C.S., Ashley, Carolyn, Plastow, Graham
Minimal research has focused on understanding mechanisms underlying porcine reproductive and respiratory syndrome virus (PRRSV) induced reproductive failure. We have completed a large-scale project investigating phenotypic and genotypic predictors of reproductive PRRS severity in which numerous...
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Maternal and Paternal Genomes Differentially Affect Myofibre Characteristics and Muscle Weights of Bovine Fetuses at Midgestation
Download2013
Kruk, Z. A., Xiang R., Rutley, D. L., Thomsen, D. A., Anderson, G. I., Fitzsimmons, C., Ghanipoor-Samami, M., Hiendleder, S., Roberts, C. T., Eindorf, T., Burns, B. M., Greenwood, P. L., Johns, W. H.
Postnatal myofibre characteristics and muscle mass are largely determined during fetal development and may be significantly affected by epigenetic parent-of-origin effects. However, data on such effects in prenatal muscle development that could help understand unexplained variation in postnatal...
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Assessing the Potential for Hybrid Vigour Within a Species: Disparate Population Breeding of Balsam Poplar
DownloadFall 2021
When two or more species are crossed to produce hybrid progeny, some of them can be expected to yield a growth performance far superior to that of either parent (i.e., hybrid vigour/heterosis). To date, there have been few attempts to examine whether hybrid vigour can be achieved by crossing...
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Spring 2023
Nutrition of the beef cow during pregnancy influences fetal development and potential changes in phenotype. On average 9-10% of beef cows are below the optimal condition score of 2.5/5 at both pre-breeding and pregnancy tests, indicating potential nutritional stress during gestation (Waldner and...
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Fall 2018
Early mammalian development cannot progress without targeted temporal and spatial expression of genes. Changing the accessibility of DNA to transcriptional machinery is one critical way gene expression is controlled. This process, known as chromatin remodeling, is vital for formation of the...
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Oral Porphyromonas gingivalis Infection Induces Epigenetic Changes that Promote Persistence of Cardiovascular Disease Risk
DownloadFall 2020
In the last two decades, periodontitis has become recognized as a risk factor for cardiovascular disease (CVD), a term that encompasses many circulatory disorders, often underpinned by atherosclerosis. One of the major questions regarding this association has been whether elimination of...
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Anti-Cancer Mechanism of Trastuzumab via Blocking Nuclear HER2 Function and Epigenetic Mechanism of Resistance
DownloadSpring 2020
HER2 receptor tyrosine kinase (encoded by ERBB2 gene) is overexpressed in approximately 25% of all breast cancer tumors (known as HER2-positive breast cancers). Overexpression of HER2 causes overactivation of downstream receptor tyrosine kinase pathways including PI3K/Akt and MAPK pathways and is...