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An examination of linking and blocking procedures for use in deflection cantilever array-based protein detection
DownloadFall 2011
In this project common linking and blocking procedures were examined for use in multiplexed deflection cantilever array-based detection of proteins. A human interferon gamma (INF-γ) enzyme-linked immunosorbent assay (ELISA) kit was used to evaluate the effectiveness of the linking and blocking...
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Computational support systems for prediction and characterization of protein crystallization outcomes
DownloadFall 2013
Analysis of protein structures may reveal their function, regulation and interactions. Almost 90% of the known protein structures were solved using X-ray crystallography; however, many more structures remain unsolved. Protein Structure Initiative (PSI) project was created to speed up structure...
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Development and Analysis of Magnetic Carbon Nanotube and Microbubble-Assisted High Centrifugation Field Techniques For The Increase of Cell Membrane Permeability
DownloadSpring 2014
To cure diseases at the gene level, therapeutic biomaterials need to enter the cells. However, since the cell membrane is a highly selective structure, its permeability is usually very low. In this thesis, we propose two innovative and efficient methods to increase cell membrane permeability....
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Spring 2018
Intrinsically disordered regions (IDRs) in proteins lack stable three dimensional structure under physiological conditions. IDRs are prevalent in nature, functionally important, and difficult to characterize experimentally due to their unstructuredness. As a result, many computational methods...
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Fall 2011
Proteins, which participate in virtually every process within cells, implement many of their functions through interactions with various ligands. Although a substantial effort in characterization and prediction of protein-ligand interactions was observed in the past two decades, these subjects...