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Skip to Search Results- 2Drug development
- 1Calcineurin
- 1Calcium sensitizer
- 1Cardiac troponin activator
- 1Immunosuppressants
- 1Nuclear magnetic resonance spectroscopy
- 1Cai, Fangze
- 1Gelozia, Shorena
- 1Hwang, Peter M.
- 1Li, Monica X.
- 1Lindert, Steffen
- 1Pineda-Sanbria, Sandra E.
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2016-01-01
Cai, Fangze, Li, Monica X., Pineda-Sanbria, Sandra E., Gelozia, Shorena, Lindert, Steffen, West, Frederick, Sykes, Brian D., Hwang, Peter M.
In cardiac and skeletal muscle, the troponin complex turns muscle contraction on and off in a calcium-dependent manner. Many small molecules are known to bind to the troponin complex to modulate its calcium binding affinity, and this may be useful in a broad range of conditions in which striated...
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Study of calcineurin interaction with inhibitor-1 and natural products. Towards novel calcineurin inhibitors
DownloadSpring 2012
Calcineurin (CaN) is an eukaryotic Ser/Thr protein phosphatase that plays an important role in lymphocyte activation. Inhibition of CaN leads to immune system suppression, a necessary procedure in organ transplantation. However, use of CaN inhibitors results in toxic side effects. The search for...