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2012

Jiang, Q., Wang, Z., Yang, R. C., Moore, S. S.

Background Linkage disequilibrium (LD) between genes at linked or independent loci can occur at gametic and zygotic levels known asgametic LD and zygotic LD, respectively. Gametic LD is well known for its roles in fine-scale mapping of quantitative trait loci, genomic selection and evolutionary...

Fall 2019

Baedke, Jessica

The development of efficacious anticancer therapies has significantly improved the prognosis of childhood cancer patients at the price of predisposing survivors to extensive chronic health problems. Although not fatal, reducing treatment-related hearing loss (ototoxicity) among childhood cancer...

2018-01-01

Waide, Emily H., Tuggle, Christopher K., Serao, Nick V. I., Schroyen, Martine, Hess, Andrew, Rowland, Raymond R. R., Lunney, Joan K., Plastow, Graham, Dekkers, Jack C. M.

Genomic prediction of the pig’s response to the porcine reproductive and respiratory syndrome (PRRS) virus (PRRSV) would be a useful tool in the swine industry. This study investigated the accuracy of genomic prediction based on porcine SNP60 Beadchip data using training and validation datasets...

2003

Brigandt, Ingo

The present paper analyzes the use and understanding of the homology concept across different biological disciplines. It is argued that in its history, the homology concept underwent a sort of adaptive radiation. Once it migrated from comparative anatomy into new biological fields, the homology...

Spring 2018

Mah, Rachel A

Choroideremia is an X-linked monogenic inherited retinal disease. It affects males starting in their teenage years with night blindness followed by progressive vision loss starting in the peripherals and ending with total vision loss late in life. It is estimated that 1 in 50,000 individuals...

Fall 2017

Luoma, Leiah M

NPAS3 encodes a transcription factor of the bHLH-PAS family, which has been robustly associated with neurodevelopmental and psychiatric disorders with intellectual disability as a common feature. NPAS3 was initially discovered as a schizophrenia-associated gene in a family with a translocation...

2017-10-31

Weber, Andrzej

SSHRC PG awarded 2018: Although 99% of human history has been lived as foragers, little is known about the contributions and experiences of individuals in hunter-gatherer groups and their role in long-term patterns of culture diversity, change, stability and resilience. We will examine these...

Fall 2021

Casey, Geoffrey A

Background: The photoreceptors are post-mitotic (no longer dividing), so the eye has evolved several unique immunological mechanisms to protect the photoreceptors and prevent vision loss. Inherited retinal disorders occur when mutations disrupt normal retinal function and photoreceptors die....

2011

Christianson, Jed, Mayerhofer, Marion, Topinka, Deborah, Good, Allen G., Mayerhofer, Reinhold

Background: Safflower, Carthamus tinctorius, is a thistle that is grown commercially for the production of oil and birdseed and recently, as a host for the production of transgenic pharmaceutical proteins. C. tinctorius can cross with a number of its wild relatives, creating the possibility of...

Fall 2020

Abdrabou, Abdalla

Rac1 is a small GTPase that belongs to the Rho family. Like other Rho family GTPases, it mediates a plethora of cellular effects, including regulation of cytoarchitecture, cell size, cell adhesion, cell polarity, cell motility, proliferation, apoptosis/survival, and membrane trafficking. The...