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Skip to Search Results- 8Department of Mechanical Engineering
- 3Department of Chemical and Materials Engineering
- 2Department of Biomedical Engineering
- 1Department of Agricultural, Food, and Nutritional Science
- 1Department of Civil and Environmental Engineering
- 1Department of Electrical and Computer Engineering
- 2Finlay, Warren (Mechanical Engineering)
- 2Uludag, Hasan (Chemical and Materials Engineering)
- 1Bhattacharjee, Subir (Mechanical Engineering)
- 1Brett, Michael (Electrical and Computer Engineering)
- 1Chang, Scott (Renewable Resources)
- 1Dr. Lingyun Chen (Agricultural, Food, and Nutritional Science)
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Fall 2012
Glancing angle deposition (GLAD) is a physical vapour deposition (PVD) technique capable of fabricating highly porous thin films with controllable film morphology on the 10 nm length scale. The GLAD process is flexible and may be used on virtually any PVD-compatible material. This makes GLAD a...
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Carbohydrate and Phosphorylcholine based Polymers Prepared by Reversible Addition-Fragmentation Chain Transfer Polymerization for Gene Therapy
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The study provides a comprehensive account on the development of novel synthetic carbohydrate and phosphorylcholine polymer based gene delivery vectors. Since the development and use of first non-viral vector for gene delivery applications, a wide range of polymers have been synthesized and...
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Characterization of Aerosol Deposition in Children and Infants Using Idealized Extrathoracic Geometries
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This thesis describes a number of experimental studies performed with the common goal of characterizing pharmaceutical aerosol deposition in children and infants using idealized extrathoracic geometries. First, an in vitro study of the recently proposed Alberta Idealized Child Throat showed that...
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Characterization of Particulate Matter Morphology and Volatility for Two Direct-Injection Engines
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Particulate matter emitted from two direct injection engines has been characterized by morphology, volatility, mass-mobility exponent, effective density, and size distribution using tandem measurements from a centrifugal particle mass analyzer (CPMA) and differential mobility analyzers (DMA). The...
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Spring 2015
Colloidal-collector interactions are of fundamental importance in separation and filtration technologies. Here, the effect of collector grains on the behavior of colloidal particles was studied in two different experimental systems, i.e., column studies with stationary collectors and batch mixing...
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Development of Empirical Models to Predict Deposition of Aerosols in the Extrathoracic Airways of Children
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The experimental studies described in this thesis were performed with the goal of measuring deposition of aerosols, inhaled either nasally or orally, in the extrathoracic airways of children in different age groups. We pursued in vitro methods and characterized the deposition of aerosols in the...
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Effects of long-term nitrogen and sulfur deposition on soil microbial communities and soil properties in the Athabasca oil sands region in northern Alberta, Canada
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Intensified oil sands activities have resulted in elevated levels of nitrogen (N) and sulfur (S) deposition in the mixedwood boreal forest in the Athabasca oil sands region (AOSR) of northern Alberta, Canada. The deposition of N and S can affect the surrounding ecosystem and it is important to...
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Hyperbranched Phosphorylcholine Polymers Synthesized via RAFT Polymerization for Gene Delivery and Synthesis of an Elastomeric Conductive Polymer for Cardiovascular Applications
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Gene therapy has the potential to treat a variety of hereditary diseases such as diabetes, peanut anaphylaxis, cystic fibrosis and different types of cancer. Gene therapy relies on the design of a delivery system which can carry a gene of interest into a cell. The delivery systems can be broken...
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Spring 2011
This thesis explores the capabilities of cationic polymers modified with lipids of different carbon chain length to deliver DNA molecules to primary cells and transformed cell lines. Our studies focus on two different polymers: polyethylenimine (PEI) and poly(L-lysine) (PLL). Firstly, PEI and PLL...
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Spring 2014
Gene delivery is an emerging therapy for treatment of many different diseases and conditions, with the first therapy recently approved for clinical use. This thesis investigates non-viral carriers for gene delivery for bone regeneration, with an emphasis on the mechanisms of plasmid DNA (pDNA)...