Search
Skip to Search Results- 20Graduate and Postdoctoral Studies (GPS), Faculty of
- 20Graduate and Postdoctoral Studies (GPS), Faculty of/Theses and Dissertations
- 8Chemical and Materials Engineering, Department of
- 8Chemical and Materials Engineering, Department of/Research Articles and Materials (Chemical and Materials Engineering)
- 4Surgery, Department of
- 4Surgery, Department of/Orthopaedic Surgery
-
Spring 2011
In this thesis, measurement and analysis of colloidal forces between an atomic force microscope (AFM) probe and a topographically patterned substrate are reported. The energy between the patterned substrate and a smooth flat plate was characterized mathematically using Surface Element Integration...
-
Interactions between Amyloid Precursor Protein and Prion Protein Impact Cell Adhesion and Apoptosis in the Developing Zebrafish
DownloadFall 2011
We report here that knockdown of either amyloid precursor protein (APP) or prion protein (PrP) in the zebrafish produces an overt dose-dependent phenotype characterized by systemic morphological defects and CNS cell death. We report findings that the zebrafish PrP-1 gene genetically interacts...
-
Interactions Between Host Trees, Bacteria, and Fungi: Impacts on Mountain Pine Beetle (Dendroctonus ponderosae) Reproduction
DownloadFall 2012
Warming winter trends due to climate change have allowed for a range expansion of the mountain pine beetle, and the beetle now threatens Canada’s economically and ecologically important jack pine forests. The beetle’s success in jack pine trees will depend upon successful colonization of the...
-
Investigating cryoinjury using simulations and experiments: 1. TF-1 cells during two-step freezing (rapid cooling interrupted with a hold time)
Download2014-09-22
McGann, L. E., Ross-Rodriguez, L. U., Elliott, J. A.
There is significant interest in designing a cryopreservation protocol for hematopoietic stem cells (HSC) which does not rely on dimethyl sulfoxide (Me2SO) as a cryoprotectant. Computer simulations that describe cellular osmotic responses during cooling and warming can be used to optimize the...
-
Modeling the transport of cryoprotective agents in articular cartilage for cryopreservation
DownloadSpring 2011
Loading vitrifiable concentrations of cryoprotective agents is an important step for cryopreservation of biological tissues by vitrification for research and transplantation purposes. This may be done by immersing the tissue in a cryoprotective agent (CPA) solution, and increasing the...
-
Fall 2015
Osteoarthritis, a disease resulting in the breakdown of cartilage and bone within joints, is a global burden that is growing in scope. There is no cure for osteoarthritis, and the current treatments are all lacking in some form or another. One treatment which attempts to prevent degeneration of...
-
Spring 2018
Graphene has created much excitement in the scientific community since 2004, when Novoselov and Geim developed a method to exfoliate atomic layers from graphite, earning them the 2010 Nobel prize. The great interest in graphene stems from its outstanding material properties such as atomic...
-
2014-09-26
Rekieh, K., Abazari, A., Elliott, J.A., Jomha, N.M., Law, G.K., McGann, L.E.
Objective: Osteochondral allografting is an effective method to treat large osteochondral defects but difficulties in tissue preservation have significantly limited the application of this technique. Successful cryopreservation of articular cartilage (AC) could improve the clinical availability...
-
Fall 2015
Cryopreserving cells for human health therapeutics is a multidisciplinary process with great complexity. Cryopreservation of human umbilical vein endothelial cells (HUVECs) has facilitated vascular biology research since they were first isolated in 1973 [59]; however identifying key variables to...