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Skip to Search Results- 1Almukainzi, May Khalifah
- 1Chen, Christopher B
- 1Dubois, Tyler
- 1Eskin, Maxim
- 1Gabr,Raniah Q
- 1Kang, Dong-Woo
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Drug Exposure Definition and Healthy User Bias Impacts on the Evaluation of Oral Anti Hyperglycemic Therapies
DownloadFall 2017
Accurate estimation of medication use is an essential component of any pharmacoepidemiological research as exposure misclassification will threaten study validity and lead to spurious associations. Many pharmacoepidemiological studies use simple definitions, such as the categorical “any versus no...
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Spring 2021
Background: Prostate cancer treatments often lead to side effects including sexual and urinary dysfunction as well as fatigue and poor quality of life. As a means of avoiding these side effects, active surveillance has been introduced as a strategy to manage men with low- to moderate-grade...
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Ganglioside Increases Metastatic Potential and Susceptibility of Prostate Cancer to Gene Therapy in vitro
DownloadFall 2009
Prostate cancer (CaP) is the 2nd most common cancer in North American men. Tumour management strategies are appropriate for early stage disease, but advanced disease has a poor prognosis and requires prompt treatment. Therefore, research into delay of tumour progression and efficacious treatment...
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Guiding treatment selection for advanced prostate cancer with biogenic silver nanoparticles
DownloadFall 2018
Prostate cancer (PCa) is the second most common cancer in men worldwide. Men with advanced PCa often face poor prognosis and are at high risk for mortality. To improve prognosis in this high risk population, targeting a reliable biological factor or marker that predicts a patient’s response...
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Impact of conventional fractionated RT to pelvic lymph nodes and dose-escalated hypofractionated RT to prostate gland using IMRT treatment delivery in high-risk prostate cancer
DownloadFall 2009
Prostate cancer is the most common cancer among Canadian men. The standard treatment in high-risk category is radical radiation, with androgen suppression treatment (AST). Significant disease progression is reported despite this approach. Radiation dose escalation has been shown to improve...
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International Comparison of Time to Treatment Intensification and Rates of Complications in Metformin Monotherapy Treated Type 2 Diabetes Patients
DownloadFall 2018
Type 2 diabetes mellitus is a progressive disease which affects many people in Canada and the United States, and the prevalence of type 2 diabetes is only expected to increase in the future. Pharmacological interventions are a cornerstone of the management of type 2 diabetes as they help to...
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Fall 2018
Human genomic data are being generated at an increasing rate owing to the advancement of high-throughput technology. Wider availability of genomics, transcriptomics, proteomics and metabolomics data motivated complex study questions with the intention to gain higher degree of understanding of...
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The application of computer simulation to investigate drug absorption and bioavailability in disease states
DownloadFall 2015
Oral drug absorption relies mainly on the physicochemical drug properties and the interaction with the physiological environment of the body. These factors could be altered significantly under abnormal conditions and disease states. Identifying these changes can optimize drug therapy under these...
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The Effect of Metformin, Flutamide and Dietary Nicotinic Acid on Dyslipidemia and Cardiometabolic Risk in the JCR:LA-cp Rodent Model of PCOS
DownloadFall 2014
Polycystic ovary syndrome (PCOS) is a highly prevalent metabolic-endocrine disorder affecting up to 18% of adolescent and adult females in their reproductive years. PCOS is associated with an increased risk of cardiovascular disease (CVD) and type 2 diabetes. Atherogenic dyslipidemia occurs in...
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The Effects of Elements of Cardiometabolic Syndrome on Metformin Disposition: Obesity and Hyperlipidemia
DownloadFall 2015
The influences of obesity, Roux-en-Y gastric bypass bariatric (RYGB) surgery and hyperlipidemia on metformin pharmacokinetics (PK) were investigated. A sensitive and novel HPLC-UV reverse phase assay method was developed and utilized. Detection and mass characterization for metformin metabolites...