Search
Skip to Search Results-
Fall 2012
Chromatin structure is important aspect of transcriptional regulation. Replication-coupled (RC) nucleosome assembly is the process of depositing newly synthesized H3-H4 onto nascent DNA behind the replication fork, mediated by the histone chaperones Asf1, CAF-1, and Rtt106. The experiments...
-
Spring 2022
The DNA damage response (DDR) is critical for maintaining genomic integrity and prevention of genotoxic consequences leading to carcinogenesis. The DDR signaling cascade results either in the activation of the repair pathway, or initiation of apoptosis if the repair is not possible. Many...
-
Fall 2017
Herpes simplex virus 1 (HSV-1) is a nuclear-replicating, double-stranded (ds) DNA virus. HSV-1 genes are expressed in a coordinate manner. The tegument protein VP16 first activates expression of the five immediate-early (IE) genes. Two IE proteins, ICP4 and ICP0, then activate early (E) and...
-
Spring 2011
Transcription and DNA replication of herpes simplex virus type 1 (HSV-1) occur in nuclear domains adjacent to structures named ND10. The HSV-1 single-stranded DNA binding protein ICP8 localizes to these nuclear domains to direct the assembly of the pre- and replication compartments. Inhibition...