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Skip to Search Results- 14Chemotherapy
- 8Colorectal cancer
- 2Body Composition
- 2Body composition
- 2Breast Cancer
- 2Liver metastases
- 1Abbasi Dezfouli, Meysam
- 1Almasud,Alaa A
- 1Ayoub, Ahmed T
- 1Bekele, Raie Taye
- 1Crisp, Nicole
- 1Ebadi, Maryam
- 6Department of Agricultural, Food, and Nutritional Science
- 3Department of Biochemistry
- 3Faculty of Nursing
- 2Faculty of Pharmacy and Pharmaceutical Sciences
- 1Department of Agricultural, Food and Nutritional Science
- 1Department of Biomedical Engineering
- 1Baracos, Vickie (Oncology and Agricultural, Food and Nutritional Science)
- 1Baracos, Vickie (Oncology)
- 1Baracos, Vickie (Oncology, Agricultural, Food, and Nutritional Science)
- 1Bell, Rhonda (Agriculture Food and Nutritional Science)
- 1Bigam, David (General Surgery)
- 1Bigam, David (Surgery)
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A Novel Comparative Analysis Approach to Personalize Chemotherapy Dose Calculation in Early Breast Cancer
DownloadFall 2018
Background Worldwide, body surface area [BSA] is used to calculate chemotherapy dose. The BSA formula was originally developed in 1916, derived from height and weight, with no consideration of other patient characteristics. Most chemotherapy agents have a narrow therapeutic index and are...
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Fall 2011
This study determined how chemotherapy treatment for colorectal cancer alters hepatic fat metabolism. Livers were isolated from tumor-bearing animals after one and two cycles of chemotherapy consisting of irinotecan plus 5-fluorouracil. Fatty acid amounts and composition within triglycerides (TG)...
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Fall 2012
Mechanisms underlying fat loss in cancer are not well understood. Knowing the types of fat being lost from adipose tissue may help define interventions to circumvent wasting. The aim of this study was to explore the differences in adipokines and fatty acid composition between visceral adipose...
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An exploration into the relationship of body composition parameters and survival outcomes in patients with resectable colorectal cancer
DownloadFall 2018
Both tumor biology and host-specific factors play an important role in the prognosis of colorectal cancer. Body composition is an emerging patient-specific factor, which is currently being elucidated. Opportunistic analysis of pre-existing staging computed tomography scans can be used to quantify...
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Fall 2010
Escalating cancer rates and an increase in the complexity and duration of chemotherapy regimens have brought the issue of cancer treatment at home to the forefront. For the participants of this study, home chemotherapy was offered as a potential treatment choice. Ten patients who accepted were...
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Cognitive Dysfunction in non-Hodgkin's Lymphoma Patients Treated with Front-Line Chemotherapy
DownloadSpring 2015
Despite the research to date, the characteristics and impact of cognitive dysfunction (CD) in cancer patients following chemotherapy is still not well understood. It is estimated approximately 20% of patients will manifest measurable cognitive deficits on neuropsychological testing...
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Fall 2015
Microtubules are cellular structures that are crucial to many cellular functions including maintenance of cell shape, vesicular transport, and cell division. The dynamic instability of microtubules is the basic feature which enables them to do their cellular functions. Their pivotal role in cell...
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Development of polymer and lipid based nano-delivery systems for targeted cancer chemotherapy
DownloadFall 2012
Conventional chemotherapy agents can kill tumor cells and inhibit tumor growth, but they produce severe side effects on normal cells at the same time. To shift the balance towards tumoral effects, it would be desirable to direct the anti-cancer drug towards tumor while restricting drug access to...
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Eicosapentaenoic and Docosahexaenoic Fatty Acids Modify Skeletal Muscle Fat Infiltration in an Animal Model of Colorectal Cancer Receiving Chemotherapy
DownloadSpring 2017
Background: Myosteatosis is defined as low skeletal muscle radio-density with elevated amounts of intermuscular adipose tissue, assessed using computed tomography. Myosteatosis has been recently observed to be associated with mortality in people with cancer. Previous work from our lab reported...