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Skip to Search Results- 4Gänzle, Michael G.
- 3Valcheva, Rosica
- 2Dieleman, Levinus
- 2Dieleman, Levinus A.
- 2Farhangfar, Arazm
- 2Field, Catherine J.
- 36Graduate and Postdoctoral Studies (GPS), Faculty of
- 36Graduate and Postdoctoral Studies (GPS), Faculty of/Theses and Dissertations
- 12Agricultural, Food and Nutritional Science, Department of
- 12Agricultural, Food and Nutritional Science, Department of/Journal Articles (Agricultural, Food and Nutritional Science)
- 3Biological Sciences, Department of
- 3Biological Sciences, Department of/Journal Articles (Biological Sciences)
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2012
Ketabi, Ali, Baracos, Vickie E., Field, Catherine J., Lin, Xiaoxi, Xue, Hongyu, Bibova, Ilona, Gänzle, Michael G., Dieleman, Levinus A., Sawyer, Michael B.
Intestinal microbiota mediate toxicity of irinotecan (CPT-11) cancer therapies and cause systemic infection after CPT-11-induced loss of barrier function. The intestinal microbiota and their functions are thus potential targets for treatment to mitigate CPT-11 toxicity. However, microbiota...
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Isomaltodextrin dose-dependently reduces colitis development in HLA-B27 rat colitis model with associated changes to gut microbiota composition and short chain fatty acid production
DownloadFall 2021
Prevalence rates for inflammatory bowel diseases (IBD) worldwide have been drastically increasing over recent decades. IBD is characterized by altered intestinal microbiome (i.e. dysbiosis), described by reduced strict butyrate-producing anaerobes versus increased facultative anaerobes in...
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Lactobacillus reuteri maintains a functional mucosal barrier during DSS treatment despite mucus layer dysfunction
Download2012
Rang, Sara, Roos, Stefan, Phillipson, Mia, Holm, Lena, Dicksved, Johan, Willing, Ben P., Petersson, Joel, Schreiber, Olof
Treatment with the probiotic bacterium Lactobacillus reuteri has been shown to prevent dextran sodium sulfate (DSS)-induced colitis in rats. This is partly due to reduced P-selectin-dependent leukocyte- and platelet-endothelial cell interactions, however, the mechanism behind this protective...
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Letter to the Editor: Comment on 'Diet quality index as a predictor of treatment efficacy in overweight and obese adolescents: The EVASYON study'
Download2020-04-01
Orsso, Camila E., Ripka, Wagner L., Prado, Carla M.
Originally published in Clinical Nutrition: https://doi.org/10.1016/j.clnu.2020.02.010
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Lipid Modified Polymers for Transfection of Human CRL Fibroblasts, and for siRNA Mediated MDR Reversal in Melanoma Cancer Therapy
DownloadFall 2010
Gene delivery for therapeutic purposes is quickly emerging as the best potential treatment option for inherited genetic diseases and cancer. Viral gene carriers have been the choice for this purpose due to their high efficiency, but harmful immunogenic and oncogenic host reactions have limited...
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Fall 2023
Background: Vitamin A status is an important health determinant. Deficiency of this micronutrient is a serious global health issue in the developing nations as the leading cause of preventable blindness in children and is a significant contributor to long-term morbidity and mortality. Nutritional...
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Na+/H+ exchange in the tumour microenvironment: Does NHE1 drive breast cancer carcinogenesis?
Download2015-01-01
Amith, Schammim Ray, Fong, Sunny, Baksh, Shairaz, Fliegel, Larry
Ionic messengers signal several critical events in carcinogenesis, including metastasis, the leading cause of patient mortality. The aberrant metabolic, proliferative and anti-apoptotic nature of neoplastic cells can be traced to the abnormal expression of their ion transporters and related...
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Nanodelivery of Novel Inhibitors of ERCC1/XPF for sensitizing colorectal cancer cell to platinum drugs
DownloadSpring 2023
This project's long-term goal is to increase the efficacy of genotoxic therapeutics through thesensitization of cells to DNA-damaging therapy ahead of the treatment. The focus of this projectwas on the enhancement of platinum-based chemotherapeutics in colorectal cancer usingcolorectal cancer...
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Non digestible carbohydrates in the diet determine toxicity of irinotecan (CPT-11)/5-fluorouracil in rats independently of β-glucuronidase activity in intestinal lumen
DownloadFall 2012
Aim of this study was to assess effects of non-digestible carbohydrates on the pathobiology of mucosal injury after chemotherapy. Rats bearing colon tumor (n=6/diet) were fed diets including 8% (w/w) as either cellulose, inulin, fructo-oligosaccharide (OligoF), 50:50 (w/w) inulin and oligoF...