Search
Skip to Search Results- 7Graduate and Postdoctoral Studies (GPS), Faculty of
- 7Graduate and Postdoctoral Studies (GPS), Faculty of/Theses and Dissertations
- 3Nursing, Faculty of
- 3Nursing, Faculty of/Chronicity
- 2Kinesiology, Sport, and Recreation, Faculty of
- 2Kinesiology, Sport, and Recreation, Faculty of/Research Data and Materials (Kinesiology, Sport, and Recreation)
-
Spring 2012
In Pulmonary Arterial Hypertension (PAH), pro-constrictive, pro-proliferative and anti-apoptotic diatheses converge to produce contraction and excessive proliferation of pulmonary artery smooth muscle cells (PASMC), a hallmark of PAH-vascular remodeling. The increased afterload causes right...
-
Spring 2011
The cardiac sodium-calcium exchanger (NCX) is an important membrane protein which regulates cellular calcium necessary for the optimal contractile function of the heart. NCX has become a focal point in ischemic heart disease (IHD) research as evidence suggests that reactive oxygen species (ROS)...
-
Molecular and cellular roles of the N-end rule pathway in apoptotic cell death in mammalian-derived cell lines
DownloadFall 2017
Cellular stresses and signaling that lead to the initiation of apoptotic pathways often result in the activation of proteases such as caspases which in turn culminate in the generation of proteolytically activated protein fragments with new or altered roles. Recent work has revealed that the...
-
Fall 2012
Despite originally being described as a secreted protease, matrix metalloproteinase‐2 (MMP‐2) was recently revealed to have targets within cardiomyocytes. The biological mechanism(s) that describes the intracellular localization of MMP‐2 is unknown and is thus the subject of this thesis....
-
Fall 2011
Taxanes are used for the treatment of breast, ovarian, and lung cancer. Unfortunately, taxane based therapy—the current treatment for metastatic breast cancer—has substantial shortcomings including myelosupression, neurotoxicity, and frequently acquired resistance. Our present understanding of...
-
Fall 2011
Taxanes are used for the treatment of breast, ovarian, and lung cancer. Unfortunately, taxane based therapy—the current treatment for metastatic breast cancer—has substantial shortcomings including myelosupression, neurotoxicity, and frequently acquired resistance. Our present understanding of...
-
PRRD Quantitative content analysis
2015-02-05
Quantitative content analysis of media collected for CIHR funded study \"Pink Ribbons and Red Dresses: the relationship between disease awareness campaigns, health-related cognitions and perceptions of preventive behaviours.\"
-
PRRD survey data - women
2015-02-05
Survey data collected for the CIHR funded study \"Pink Ribbons and Red Dresses: the relationship between disease awareness campaigns, health-related cognitions and perceptions of preventive behaviours.\"