Search
Skip to Search Results- 5Xenotransplantation
- 2Diabetes
- 2Islet transplantation
- 2Neonatal Porcine Islets
- 2Neonatal porcine islets
- 1Antibody
-
Evaluation of the Protection Induced by a Monotherapy of Anti-LFA-1 Monoclonal Antibody and Co-transplantation of Neonatal Porcine Islets with Sertoli Cells
DownloadSpring 2012
Two major barriers to islet transplantation are the need for an unlimited source of donor tissue and a safer method of immunosuppression. These may be overcome by xenotransplantation of neonatal porcine islets (NPI) along with combined co-transplantation of neonatal porcine Sertoli cells (SC)...
-
Fall 2019
Diabetes is a chronic metabolic condition characterized by hyperglycemia resulting from impaired glucose metabolism. Type 1 diabetes mellitus (T1DM) is a result of progressive autoimmune destruction of insulin-producing pancreatic beta (β)-cells. By far, parenteral insulin replacement is...
-
Fall 2009
Islet transplantation has the potential to be an effective treatment for patients with type 1 diabetes. However, a shortage of human donor islets and the need for continuous immunosuppressive therapy currently limit this therapy to patients with brittle type 1 diabetes. Neonatal pigs may...
-
Tolerance to neonatal porcine islet xenografts induced by a combination of monoclonal antibodies
DownloadFall 2009
Islet transplantation is a more physiological way to treat type 1 diabetes. However, shortage of donor tissue and chronic administration of immune suppressive drugs has limited the widespread application of this therapy for all patients with type 1 diabetes, particularly children suffering from...
-
Fall 2015
The development of the Edmonton protocol was an important milestone in the process of establishing islet transplantation as a cure for diabetes. However, many challenges must still be overcome, including the shortage of donor organs. To address this issue, we believe that neonatal porcine islets...