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- 52Graduate and Postdoctoral Studies (GPS), Faculty of/Theses and Dissertations
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A Multi-perspective Concept Mapping Study of Head and Neck Cancer Treatment Outcome Priorities
DownloadFall 2020
Background Head and neck cancer treatments have been showing promising outcomes, yet they often have significant impact on patients. With an approximate 50% survival rate, individuals with a history of this type of cancer are living with long term challenges. With the increasing focus on...
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A Pan Canadian Practice Guideline for Screening, Assessment, and Management of Cancer-Related Fatigue in Adults (Version 2)
Download2015-01-01
Howell, Doris, Keshavarz, Homa, Broadfield, Larry, Hack, Tom, Hamel, Marc, Harth, Tamara, Jones, Jennifer, McLeod, Deborah, Olson, Karin, Phan, Stephanie, Sawka, Annie, Swinton, Nelda, Ali, Muhammad U.
Background Cancer-related fatigue (CRF) is a prevalent problem in cancer and has a side effect of treatment that often worsens during cancer treatment and can persist as a long-term problem for many patients including those in palliative care and cancer survivor populations. Reported prevalence...
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Spring 2013
Polycomb protein methyltransferase, Enhancer of Zeste 2 (Ezh2), is frequently overexpressed in human malignancy and is implicated in cancer cell proliferation and invasion. Recently, several other polycomb proteins have been implicated in modulating the response to DNA double strand breaks, and...
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Fall 2015
DNA is a detailed layout of instructions for cellular function. The integrity of human DNA is constantly challenged by a barrage of exogenous and endogenous sources. A regime of genome stability maintenance has evolved to repair the many different types of DNA damage. A form of communication...
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2014
van Zanten, S.V., Chang, H.J., Morse, A., Lefebvre, M., Goodman, K.J.
Introduction. Helicobacter pylori infection is an emerging health concern to some northern Canadian Aboriginal communities and their clinicians. Clinicians in the north perceive H. pylori infection to be a major clinical problem because they find H. pylori infection in many patients evaluated for...
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Adiposity and fat loss in cancer: Exploring the prognostic significance and underlying mechanisms of adipose alterations in cancer
DownloadSpring 2017
During cancer progression, many patients will experience some degree of wasting of both muscle and adipose tissue. However, little is-known about adipose tissue alterations after a cancer diagnosis. Therefore, this research was conducted to first understand the prognostic significance of adipose...
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Anti-Cancer Mechanism of Trastuzumab via Blocking Nuclear HER2 Function and Epigenetic Mechanism of Resistance
DownloadSpring 2020
HER2 receptor tyrosine kinase (encoded by ERBB2 gene) is overexpressed in approximately 25% of all breast cancer tumors (known as HER2-positive breast cancers). Overexpression of HER2 causes overactivation of downstream receptor tyrosine kinase pathways including PI3K/Akt and MAPK pathways and is...
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Fall 2009
There is substantial evidence of the elevated risk of cancer among individuals with type 2 diabetes. Very little is known, however, about the role that antidiabetic therapies play in this relationship. The objective of this program of research was to examine whether there is a therapeutic risk...
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Application of ROC curve analysis to metabolomics data sets for the detection of cancer in a mouse model
DownloadFall 2010
The goal of this study was to show that quantifiable metabolic changes may be used to screen for cancer. NIH III nude mice (n=22) were injected with human GBM cells, with daily urine samples collected pre and post-injection. 14 mice were injected with saline to serve as controls. The...