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Skip to Search Results- 2Prado, Carla M.
- 1Almasud, Alaa A
- 1Baracos, Vickie E.
- 1Bekaii-Saab, Tanios
- 1Cushen, Samantha J.
- 1Daly, Louise
- 5Graduate and Postdoctoral Studies (GPS), Faculty of
- 5Graduate and Postdoctoral Studies (GPS), Faculty of/Theses and Dissertations
- 3Agricultural, Food and Nutritional Science, Department of
- 3Agricultural, Food and Nutritional Science, Department of/Journal Articles (Agricultural, Food and Nutritional Science)
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Spring 2010
This thesis presents Pathway Informed Analysis (PIA), a classification method for predicting disease states (diagnosis) from metabolic profile measurements that incorporates biological knowledge in the form of metabolic pathways. A metabolic pathway describes a set of chemical reactions that...
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Cancer-associated malnutrition, cachexia and sarcopenia: the skeleton in the hospital closet 40 years later
Download2016-01-20
Ryan, Aoife M., Power, Derek G., Daly, Louise, Cushen, Samantha J., Ní Bhuachalla, Ēadaoin, Prado, Carla M.
An awareness of the importance of nutritional status in hospital settings began more than 40 years ago. Much has been learned since and has altered care. For the past 40 years several large studies have shown that cancer patients are amongst the most malnourished of all patient groups. Recently,...
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Does IGFR1 inhibition result in increased muscle mass loss in patients undergoing treatment for pancreatic cancer?
Download2014
Shroff, R., Katz, M. H., Overman, M. J., Khalil, M., Lieffers, J., Varadhachary, G. R., Fogelman, D., Javle, M. , Holmes, H., Prado, C. M.
BackgroundIGF-1 plays a role in the growth of multiple tumor types, including pancreatic cancer. IGF-1 also serves as a growth factor for muscle. The impact of therapeutic targeting of IGF-1 on muscle mass is unknown.MethodsWe evaluated muscle mass at L3 in patients enrolled in a randomized phase...
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Elevated Fatty Acid Content in Muscle is Prevented by EPA and DHA in an Animal Model of Colorectal Cancer Receiving CPT-11 / 5-FU
DownloadFall 2012
This study aimed to assess the effect of irinotecan / 5-fluorouracil treatment on amount and types of fatty acids in skeletal muscles of tumor-bearing rats fed: a) control diet, b) fish oil diet. Rats bearing the Ward colorectal carcinoma were fed a semi-purified diet with or without fish oil...
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Microtubules and Energy Metabolism: Targets for Standard, Combination, and Novel Therapeutic Interventions and Monitoring of Cancer
DownloadSpring 2016
The challenge of understanding and treating cancer has proven to be exceedingly complex. At this juncture, understanding cancer from the perspective of a breakdown of a complex cooperative system using a biophysical analysis may aid in improved treatments and prevention of this disease. In any...
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Skeletal muscle anabolism is a side effect of therapy with the MEK inhibitor: Selumetinib in patients with cholangiocarcinoma
Download2012
Ghosh, Sunita, Doyle, L. Austin, Baracos, Vickie E., Prado, Carla M., Sawyer, Michael B., Bekaii-Saab, Tanios, Shrestha, Suraj
background: Cancer cachexia is characterised by skeletal muscle wasting; however, potential for muscle anabolism in patients with advanced cancer is unproven. methods: Quantitative analysis of computed tomography images for loss/gain of muscle in cholangiocarcinoma patients receiving selumetinib...
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Fall 2014
The purpose of this work is to understand properties of skeletal muscle of cancer patients experiencing severe muscle depletion. These studies were done using computed tomography (CT) imaging and patient information (demographics), and collection of muscle biopsies to analyze using flow...
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Fall 2013
Cancer cachexia is a multifactorial syndrome characterized by involuntary weight loss, wasting of skeletal muscle driven by reduced food intake and abnormal metabolism. Cachexia has a negative impact on quality of life, response to chemotherapy and survival. Cachexia research is undeveloped with...